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PXD011285

PXD011285 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleP. yoelii exos .
DescriptionExosomes are a subclass of nanometer-sized vesicles formed by the endocytic pathway which contain genetic and protein material and reflect the contents of their cells of origin. In Plasmodium infections, vesicles derived from the parasite or parasite-infected cells have been shown to induce the expression of pro-inflammatory elements, which have been correlated with manifestations of clinic disease. Thus, these vesicles are of great interest as therapeutic targets, or as vehicles for immunomodulatory control. Herein, the identification and characterization of proteins within naturally occurring exosomes from a rodent Plasmodium yoelii infection is described. Our results establish that exosomes derived from an infection with P. yoelii contain proteins of interest as vaccine candidates (e.g. p235 rhoptry protein, multiple members of the yir multi-gene protein family, and the ribosomal protein S12), uncharacterized proteins which may be good targets of T cell immunoreactivity, and proteins involved in metabolic processes, homeostasis and immunity. These findings add to the growing interest on parasite exosomes and provide a different way to understand the interactions between host and parasite and identify novel proteins potentially targeted by protective immune responses. Together with evidence that exosomes can interact with the host immune system and generate an immune response, these data provide a solid foundation for future studies aimed at novel vaccination strategies in the context of parasitic diseases, where the classical approaches that have thus far failed.
HostingRepositoryPRIDE
AnnounceDate2024-10-07
AnnouncementXMLSubmission_2024-10-07_10:19:11.701.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterKarina de Sousa
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Plasmodium yoelii yoelii 17XNL; NCBI TaxID: 352914;
ModificationListmonohydroxylated residue; iodoacetic acid derivatized residue
InstrumentTripleTOF 5600
Dataset History
RevisionDatetimeStatusChangeLog Entry
02018-10-05 01:12:59ID requested
12024-10-07 10:19:12announced
Publication List
10.1016/j.ijpara.2021.06.001;
De Sousa KP, Potriquet J, Mulvenna J, Sotillo J, Groves PL, Loukas A, Apte SH, Doolan DL, Proteomic identification of the contents of small extracellular vesicles from in vivo Plasmodium yoelii infection. Int J Parasitol, 52(1):35-45(2022) [pubmed]
Keyword List
curator keyword: Biological
submitter keyword: yoelii, exosomes,malaria
Contact List
Denise L. Doolan
contact affiliationJames Cook University, Cairns Campus, QLD Australia
contact emaildenise.doolan@jcu.edu.au
lab head
Karina de Sousa
contact affiliationQIMR Berghofer MRI
contact emailkarina.piresdesousa@uq.net.au
dataset submitter
Full Dataset Link List
Dataset FTP location
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