PXD011285

PXD011285 is an original dataset announced via ProteomeXchange.

Title	P. yoelii exos .
Description	Exosomes are a subclass of nanometer-sized vesicles formed by the endocytic pathway which contain genetic and protein material and reflect the contents of their cells of origin. In Plasmodium infections, vesicles derived from the parasite or parasite-infected cells have been shown to induce the expression of pro-inflammatory elements, which have been correlated with manifestations of clinic disease. Thus, these vesicles are of great interest as therapeutic targets, or as vehicles for immunomodulatory control. Herein, the identification and characterization of proteins within naturally occurring exosomes from a rodent Plasmodium yoelii infection is described. Our results establish that exosomes derived from an infection with P. yoelii contain proteins of interest as vaccine candidates (e.g. p235 rhoptry protein, multiple members of the yir multi-gene protein family, and the ribosomal protein S12), uncharacterized proteins which may be good targets of T cell immunoreactivity, and proteins involved in metabolic processes, homeostasis and immunity. These findings add to the growing interest on parasite exosomes and provide a different way to understand the interactions between host and parasite and identify novel proteins potentially targeted by protective immune responses. Together with evidence that exosomes can interact with the host immune system and generate an immune response, these data provide a solid foundation for future studies aimed at novel vaccination strategies in the context of parasitic diseases, where the classical approaches that have thus far failed.
HostingRepository	PRIDE
AnnounceDate	2024-10-07
AnnouncementXML	Submission_2024-10-07_10:19:11.701.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Karina de Sousa
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Plasmodium yoelii yoelii 17XNL; NCBI TaxID: 352914;
ModificationList	monohydroxylated residue; iodoacetic acid derivatized residue
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2018-10-05 01:12:59	ID requested
⏵ 1	2024-10-07 10:19:12	announced

10.1016/j.ijpara.2021.06.001;

De Sousa KP, Potriquet J, Mulvenna J, Sotillo J, Groves PL, Loukas A, Apte SH, Doolan DL, Proteomic identification of the contents of small extracellular vesicles from in vivo Plasmodium yoelii infection. Int J Parasitol, 52(1):35-45(2022) [pubmed]

curator keyword: Biological

submitter keyword: yoelii, exosomes,malaria

Denise L. Doolan
contact affiliation	James Cook University, Cairns Campus, QLD Australia
contact email	denise.doolan@jcu.edu.au
lab head
Karina de Sousa
contact affiliation	QIMR Berghofer MRI
contact email	karina.piresdesousa@uq.net.au
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/07/PXD011285

PRIDE project URI

• PRIDE
  1. PXD011285
     1. Label: PRIDE project
     2. Name: P. yoelii exos