PXD011276

PXD011276 is an original dataset announced via ProteomeXchange.

Title	The Synovial Fluid Proteome Differentiates between Septic and Nonseptic Articular Pathologies
Description	Presently few studies have investigated the proteomic profile of equine synovial fluid (SF) using high mass resolution mass spectrometer and in-solution trypsin digestion and to our knowledge none have investigated protein profile changes septic SF in any species. In this study we have used mass spectrometry and label-free quantification to identify potential protein biomarkers that allow differentiation between equine articular joint pathologies, potentially aiding accurate diagnosis and enabling increased understanding of the effect of septic synovitis on the joint environment. Identification of characteristic proteomic profiles in synovial sepsis would increase the understanding of the molecular basis of the condition and also allow the identification of potential biomarkers for early diagnosis and treatment of the disease. We hypothesised that proteomic profile characteristics will distinguish septic from non-septic equine arthropathies and between the non-septic common arthropathies osteochondrosis and OA.
HostingRepository	PRIDE
AnnounceDate	2019-05-01
AnnouncementXML	Submission_2019-05-29_04:04:43.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD011276
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Aibek Smagul
SpeciesList	scientific name: Equus caballus (Horse); NCBI TaxID: 9796;
ModificationList	Oxidation; Carbamidomethyl
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2018-10-04 01:39:46	ID requested
1	2019-05-01 07:55:02	announced
⏵ 2	2019-05-29 04:04:44	announced	Updated publication reference for PubMed record(s): 31028944.

Anderson JR, Smagul A, Simpson D, Clegg PD, Rubio-Martinez LM, Peffers MJ, The synovial fluid proteome differentiates between septic and nonseptic articular pathologies. J Proteomics, 202():103370(2019) [pubmed]

curator keyword: Biological, Biomedical

submitter keyword: Synovial fluid, proteomics, sepsis

Mandy Jayne Peffers
contact affiliation	Institute of Ageing and Chronic Disease, University of Liverpool, United Kingdom
contact email	peffs@liverpool.ac.uk
lab head
Aibek Smagul
contact affiliation	University of Liverpool
contact email	aibek@liverpool.ac.uk
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD011276
     1. Label: PRIDE project
     2. Name: The Synovial Fluid Proteome Differentiates between Septic and Nonseptic Articular Pathologies