PXD011192
PXD011192 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | iTRAQ-based differential proteomic analysis in Sprague Dawley rats and Kunming mice brains chronically infected with type II Toxoplasma gondii strain (Prugniaud) |
| Description | We artificially infected Sprague Dawley (SD) rats and Kunming (KM) mice with type II Toxoplasma gondii (T. gondii) strain (Prugniaud, Pru) to generate toxoplasmosis, which is a fatal disease mediated by T. gondii invasion in the central nervous system (CNS) with unknown mechanisms. We aimed to explore the mechanism of differential susceptibility of mice and rats to T. gondii infection. Therefore, we established a strategy of isobaric tags for relative and absolute quantitation (iTRAQ) to identify differentially expressed proteins (DEPs) of the rats’ and the mice’s brains compared to the healthy groups. |
| HostingRepository | iProX |
| AnnounceDate | 2018-09-25 |
| AnnouncementXML | Submission_2023-08-28_00:13:08.042.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Wanyi Huang |
| SpeciesList | scientific name: Rattus norvegicus; NCBI TaxID: 10116; scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | iTRAQ8plex reporter+balance reagent acylated residue |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2018-09-26 09:23:09 | ID requested | |
| 1 | 2018-09-26 09:23:26 | announced | |
| ⏵ 2 | 2023-08-28 00:13:08 | announced | 2023-08-28: Update information. |
Publication List
| Lv L, Wang Y, Feng W, Hernandez JA, Huang W, Zheng Y, Zhou X, Lv S, Chen Y, Yuan ZG, iTRAQ-based differential proteomic analysis in Mongolian gerbil brains chronically infected with Toxoplasma gondii. J Proteomics, 160():74-83(2017) [pubmed] |
Keyword List
| submitter keyword: Sprague Dawley rats, Kunming mice, Toxoplasma gondii ,Prugniaud |
Contact List
| Ziguo Yuan | |
|---|---|
| contact affiliation | College of Veterinary Medicine, South China Agricultural University |
| contact email | ziguoyuan@scau.edu.cn |
| lab head | |
| Wanyi Huang | |
| contact affiliation | College of Veterinary Medicine, South China Agricultural University |
| contact email | 653922713@qq.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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