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PXD011192

PXD011192 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleiTRAQ-based differential proteomic analysis in Sprague Dawley rats and Kunming mice brains chronically infected with type II Toxoplasma gondii strain (Prugniaud)
DescriptionWe artificially infected Sprague Dawley (SD) rats and Kunming (KM) mice with type II Toxoplasma gondii (T. gondii) strain (Prugniaud, Pru) to generate toxoplasmosis, which is a fatal disease mediated by T. gondii invasion in the central nervous system (CNS) with unknown mechanisms. We aimed to explore the mechanism of differential susceptibility of mice and rats to T. gondii infection. Therefore, we established a strategy of isobaric tags for relative and absolute quantitation (iTRAQ) to identify differentially expressed proteins (DEPs) of the rats’ and the mice’s brains compared to the healthy groups.
HostingRepositoryiProX
AnnounceDate2018-09-25
AnnouncementXMLSubmission_2023-08-28_00:13:08.042.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterWanyi Huang
SpeciesList scientific name: Rattus norvegicus; NCBI TaxID: 10116; scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationListiTRAQ8plex reporter+balance reagent acylated residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02018-09-26 09:23:09ID requested
12018-09-26 09:23:26announced
22023-08-28 00:13:08announced2023-08-28: Update information.
Publication List
Lv L, Wang Y, Feng W, Hernandez JA, Huang W, Zheng Y, Zhou X, Lv S, Chen Y, Yuan ZG, iTRAQ-based differential proteomic analysis in Mongolian gerbil brains chronically infected with Toxoplasma gondii. J Proteomics, 160():74-83(2017) [pubmed]
Keyword List
submitter keyword: Sprague Dawley rats, Kunming mice, Toxoplasma gondii ,Prugniaud
Contact List
Ziguo Yuan
contact affiliationCollege of Veterinary Medicine, South China Agricultural University
contact emailziguoyuan@scau.edu.cn
lab head
Wanyi Huang
contact affiliationCollege of Veterinary Medicine, South China Agricultural University
contact email653922713@qq.com
dataset submitter
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iProX dataset URI