PXD011191

PXD011191 is an original dataset announced via ProteomeXchange.

Title	salmonella proteome
Description	Here we conducted the first comparative study of S. Typhimurium proteomic remodeling within macrophages versus epithelial cells. In addition to many shared features, our data revealed proteomic signatures highly specific to one type of host cells. Notably, intracellular S. Typhimurium differentially regulates the two type III secretion systems (T3SSs) far quicker in macrophages than in epithelial cells, so do bacterial flagellar and chemotaxis systems degenerate. Importantly, our comparative analysis uncovered vast induction of histidine biosynthesis in macrophages but not in epithelial cells, which is attributed to differing levels of intracellular histidine as well as defective biosynthetic pathways of this amino acid.
HostingRepository	iProX
AnnounceDate	2018-09-26
AnnouncementXML	Submission_2018-09-26_09:22:38.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Zezhou Li
SpeciesList	scientific name: Salmonella enterica subsp. enterica serovar Typhimurium str. LT2; NCBI TaxID: 99287;
ModificationList	monohydroxylated residue
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2018-09-26 09:22:17	ID requested
⏵ 1	2018-09-26 09:22:39	announced

Dataset with its publication pending

submitter keyword: Salmonella proteome, bacterial infection, the his operon, mass spectrometry

Xiaoyun Liu
contact affiliation	Institute of Analytical Chemistry and Synthetic and Functional Biomolecules Center
contact email	xiaoyun.liu@pku.edu.cn
lab head
Zezhou Li
contact affiliation	Institute of Analytical Chemistry and Synthetic and Functional Biomolecules Center
contact email	1601110285@pku.edu.cn
dataset submitter

iProX dataset URI