PXD011181

PXD011181 is an original dataset announced via ProteomeXchange.

Title	Rat atria-2D LC-MS/MS - Atrial electrophysiological and molecular remodelling induced by obstructive sleep apnoea
Description	To understand the molecular change occurring in the atria during obstructive sleep apnea, we have implemented a rat model of OSA involving the surgical implantation of a tracheal obstructive device, allowing the rats to remain conscious and free-roaming throughout 2 weeks of apnea administration. Rats were divided into severe and moderate apnea groups, receiving a 23 second or 13 second apneas per minute, respectively. The two-dimensional polyacrylamide gel electrophoresis (2D PAGE) of atrial homogenates to compare the dysregulations in the protein pattern in severe and moderate apnea when compared to control.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:14:52.018.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD011181
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Devika Channaveerappa
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	Propionamide; Oxidation
Instrument	Xevo G2 Q-Tof

Revision	Datetime	Status	ChangeLog Entry
0	2018-09-24 07:41:01	ID requested
1	2019-02-21 03:54:18	announced
⏵ 2	2024-10-22 04:14:59	announced	2024-10-22: Updated project metadata.

10.1111/jcmm.13145;

10.1111/jcmm.14131;

10.6019/PXD011181;

Channaveerappa D, Lux JC, Wormwood KL, Heintz TA, McLerie M, Treat JA, King H, Alnasser D, Goodrow RJ, Ballard G, Decker R, Darie CC, Panama BK, Atrial electrophysiological and molecular remodelling induced by obstructive sleep apnoea. J Cell Mol Med, 21(9):2223-2235(2017) [pubmed]

Lux JC, Channaveerappa D, Aslebagh R, Heintz TA, McLerie M, Panama BK, Darie CC, Identification of dysregulation of atrial proteins in rats with chronic obstructive apnea using two-dimensional polyacrylamide gel electrophoresis and mass spectrometry. J Cell Mol Med, 23(4):3016-3020(2019) [pubmed]

curator keyword: Biomedical

submitter keyword: rat, protein dysregulations, atria

Costel C. Darie
contact affiliation	Biochemistry and Proteomics group, Department of Chemistryand Biomolecular Science, Clarkson University, NY, USA
contact email	cdarie@clarkson.edu
lab head
Devika Channaveerappa
contact affiliation	Clarkson University
contact email	channad@clarkson.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/02/PXD011181

PRIDE project URI

• PRIDE
  1. PXD011181
     1. Label: PRIDE project
     2. Name: Rat atria-2D LC-MS/MS - Atrial electrophysiological and molecular remodelling induced by obstructive sleep apnoea