PXD011170

PXD011170 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Arzanol Biomolecular Targets
Description	The interactome of arzanol was investigated by MS-based chemical proteomics, a pioneering technology for small molecules target discovery. Brain glycogen phosphorylase (bGP), a key regulator of glucose metabolism so far refractory to small molecule modulation, was identified as the main high-affinity target of arzanol. Competitive affinity-based proteomics, DARTS, molecular docking, and in vitro biological assays provided molecular mechanistic insights on the arzanol-enzyme interaction, qualifying this positive modulator of bGP for further studies in the realm of neurodegeneration and cancer.
HostingRepository	PRIDE
AnnounceDate	2019-03-25
AnnouncementXML	Submission_2019-03-25_09:30:52.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD011170
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Maria Chiara Monti
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	Phospho; Oxidation; Carbamidomethyl
Instrument	LTQ Orbitrap

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2018-09-24 05:15:55	ID requested
⏵ 1	2019-03-25 09:30:53	announced

Publication List

Del Gaudio F, Pollastro F, Mozzicafreddo M, Riccio R, Minassi A, Monti MC, Chemoproteomic fishing identifies arzanol as a positive modulator of brain glycogen phosphorylase. Chem Commun (Camb), 54(91):12863-12866(2018) [pubmed]

Del Gaudio F, Pollastro F, Mozzicafreddo M, Riccio R, Minassi A, Monti MC, Chemoproteomic fishing identifies arzanol as a positive modulator of brain glycogen phosphorylase. Chem Commun (Camb), 54(91):12863-12866(2018) [pubmed]

Keyword List

curator keyword: Biomedical
submitter keyword: Arzanol, brain Glycogen Phosphorylase, chemical proteomics

curator keyword: Biomedical

submitter keyword: Arzanol, brain Glycogen Phosphorylase, chemical proteomics

Contact List

Maria Chiara Monti
contact affiliation	Dept of Pharmacy, University of Salerno
contact email	mcmonti@unisa.it
lab head
Maria Chiara Monti
contact affiliation	Dept Pharmacy University of Salerno
contact email	mcmonti@unisa.it
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/03/PXD011170
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/03/PXD011170

PRIDE project URI

Repository Record List

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