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PXD011154

PXD011154 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleComparative analysis of Salmonella Typhi, Paratyphi A, Enteritidis and Typhimurium core proteomes
DescriptionSalmonella enterica subsp. enterica contains more than 2,600 serovars of which four are of major medical relevance for humans. While the typhoidal serovars (Typhi and Paratyphi A) are human-restricted and cause enteric fever, non-typhoidal Salmonella serovars (Typhimurium and Enteritidis) have a broad host range and predominantly cause gastroenteritis. In this study, we compared the core proteomes of Salmonella Typhi, Paratyphi A, Typhimurium and Enteritidis using contemporary proteomics. Five isolates, covering different geographical origins, and one reference strain per serovar were grown in vitro to the exponential phase. Protein levels of orthologous proteins between serovars were compared and subjected to gene ontology term enrichment and inferred regulatory interactions. Differential expression of the core proteomes of the typhoidal serovars appears mainly related to cell surface components and, for the non-typhoidal serovars, to pathogenicity. Our findings may guide future development of novel diagnostics and vaccines, and understanding of disease progression.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_04:15:37.934.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterSara Saleh
SpeciesList scientific name: Salmonella typhimurium (strain 14028s / SGSC 2262); NCBI TaxID: 588858; scientific name: Salmonella enterica subsp. enterica serovar Typhi str. CT18; NCBI TaxID: 220341; scientific name: Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150; NCBI TaxID: 295319; scientific name: Salmonella enterica subsp. enterica serovar Enteritidis str. P125109; NCBI TaxID: 550537;
ModificationList2-pyrrolidone-5-carboxylic acid (Gln); formylated residue; monohydroxylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02018-09-20 04:59:16ID requested
12019-05-13 03:56:07announced
22019-06-14 00:28:48announcedUpdated publication reference for PubMed record(s): 31125353.
32024-10-22 04:15:41announced2024-10-22: Updated project metadata.
Publication List
10.1371/journal.pntd.0007416;
Saleh S, Van Puyvelde S, Staes A, Timmerman E, Barb, é B, Jacobs J, Gevaert K, Deborggraeve S, Salmonella Typhi, Paratyphi A, Enteritidis and Typhimurium core proteomes reveal differentially expressed proteins linked to the cell surface and pathogenicity. PLoS Negl Trop Dis, 13(5):e0007416(2019) [pubmed]
Keyword List
curator keyword: Biomedical
submitter keyword: comparative analysis,Typhoidal Salmonella, non-typhoidal Salmonella, core proteome
Contact List
Stijn Deborggraeve
contact affiliationDepartment of Biomedical Sciences, unit of Diagnostic Bacteriology, Institute of Tropical Medicine
contact emailsdeborggraeve@itg.be
lab head
Sara Saleh
contact affiliationUniversity of Ghent - Faculty of Medicine and Health Sciences - Department of Biochemistry
contact emailssaleh@itg.be
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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