PXD011154

PXD011154 is an original dataset announced via ProteomeXchange.

Title	Comparative analysis of Salmonella Typhi, Paratyphi A, Enteritidis and Typhimurium core proteomes
Description	Salmonella enterica subsp. enterica contains more than 2,600 serovars of which four are of major medical relevance for humans. While the typhoidal serovars (Typhi and Paratyphi A) are human-restricted and cause enteric fever, non-typhoidal Salmonella serovars (Typhimurium and Enteritidis) have a broad host range and predominantly cause gastroenteritis. In this study, we compared the core proteomes of Salmonella Typhi, Paratyphi A, Typhimurium and Enteritidis using contemporary proteomics. Five isolates, covering different geographical origins, and one reference strain per serovar were grown in vitro to the exponential phase. Protein levels of orthologous proteins between serovars were compared and subjected to gene ontology term enrichment and inferred regulatory interactions. Differential expression of the core proteomes of the typhoidal serovars appears mainly related to cell surface components and, for the non-typhoidal serovars, to pathogenicity. Our findings may guide future development of novel diagnostics and vaccines, and understanding of disease progression.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:15:37.934.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Sara Saleh
SpeciesList	scientific name: Salmonella typhimurium (strain 14028s / SGSC 2262); NCBI TaxID: 588858; scientific name: Salmonella enterica subsp. enterica serovar Typhi str. CT18; NCBI TaxID: 220341; scientific name: Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150; NCBI TaxID: 295319; scientific name: Salmonella enterica subsp. enterica serovar Enteritidis str. P125109; NCBI TaxID: 550537;
ModificationList	2-pyrrolidone-5-carboxylic acid (Gln); formylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2018-09-20 04:59:16	ID requested
1	2019-05-13 03:56:07	announced
2	2019-06-14 00:28:48	announced	Updated publication reference for PubMed record(s): 31125353.
⏵ 3	2024-10-22 04:15:41	announced	2024-10-22: Updated project metadata.

10.1371/journal.pntd.0007416;

Saleh S, Van Puyvelde S, Staes A, Timmerman E, Barb, é B, Jacobs J, Gevaert K, Deborggraeve S, Salmonella Typhi, Paratyphi A, Enteritidis and Typhimurium core proteomes reveal differentially expressed proteins linked to the cell surface and pathogenicity. PLoS Negl Trop Dis, 13(5):e0007416(2019) [pubmed]

curator keyword: Biomedical

submitter keyword: comparative analysis,Typhoidal Salmonella, non-typhoidal Salmonella, core proteome

Stijn Deborggraeve
contact affiliation	Department of Biomedical Sciences, unit of Diagnostic Bacteriology, Institute of Tropical Medicine
contact email	sdeborggraeve@itg.be
lab head
Sara Saleh
contact affiliation	University of Ghent - Faculty of Medicine and Health Sciences - Department of Biochemistry
contact email	ssaleh@itg.be
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/05/PXD011154

PRIDE project URI

• PRIDE
  1. PXD011154
     1. Label: PRIDE project
     2. Name: Comparative analysis of Salmonella Typhi, Paratyphi A, Enteritidis and Typhimurium core proteomes