PXD011154 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Comparative analysis of Salmonella Typhi, Paratyphi A, Enteritidis and Typhimurium core proteomes |
Description | Salmonella enterica subsp. enterica contains more than 2,600 serovars of which four are of major medical relevance for humans. While the typhoidal serovars (Typhi and Paratyphi A) are human-restricted and cause enteric fever, non-typhoidal Salmonella serovars (Typhimurium and Enteritidis) have a broad host range and predominantly cause gastroenteritis. In this study, we compared the core proteomes of Salmonella Typhi, Paratyphi A, Typhimurium and Enteritidis using contemporary proteomics. Five isolates, covering different geographical origins, and one reference strain per serovar were grown in vitro to the exponential phase. Protein levels of orthologous proteins between serovars were compared and subjected to gene ontology term enrichment and inferred regulatory interactions. Differential expression of the core proteomes of the typhoidal serovars appears mainly related to cell surface components and, for the non-typhoidal serovars, to pathogenicity. Our findings may guide future development of novel diagnostics and vaccines, and understanding of disease progression. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_04:15:37.934.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Sara Saleh |
SpeciesList | scientific name: Salmonella typhimurium (strain 14028s / SGSC 2262); NCBI TaxID: 588858; scientific name: Salmonella enterica subsp. enterica serovar Typhi str. CT18; NCBI TaxID: 220341; scientific name: Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150; NCBI TaxID: 295319; scientific name: Salmonella enterica subsp. enterica serovar Enteritidis str. P125109; NCBI TaxID: 550537; |
ModificationList | 2-pyrrolidone-5-carboxylic acid (Gln); formylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2018-09-20 04:59:16 | ID requested | |
1 | 2019-05-13 03:56:07 | announced | |
2 | 2019-06-14 00:28:48 | announced | Updated publication reference for PubMed record(s): 31125353. |
⏵ 3 | 2024-10-22 04:15:41 | announced | 2024-10-22: Updated project metadata. |
Publication List
10.1371/journal.pntd.0007416; |
Saleh S, Van Puyvelde S, Staes A, Timmerman E, Barb, é B, Jacobs J, Gevaert K, Deborggraeve S, Salmonella Typhi, Paratyphi A, Enteritidis and Typhimurium core proteomes reveal differentially expressed proteins linked to the cell surface and pathogenicity. PLoS Negl Trop Dis, 13(5):e0007416(2019) [pubmed] |
Keyword List
curator keyword: Biomedical |
submitter keyword: comparative analysis,Typhoidal Salmonella, non-typhoidal Salmonella, core proteome |
Contact List
Stijn Deborggraeve |
contact affiliation | Department of Biomedical Sciences, unit of Diagnostic Bacteriology, Institute of Tropical Medicine |
contact email | sdeborggraeve@itg.be |
lab head | |
Sara Saleh |
contact affiliation | University of Ghent - Faculty of Medicine and Health Sciences - Department of Biochemistry |
contact email | ssaleh@itg.be |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/05/PXD011154 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD011154
- Label: PRIDE project
- Name: Comparative analysis of Salmonella Typhi, Paratyphi A, Enteritidis and Typhimurium core proteomes