PXD011153

PXD011153 is an original dataset announced via ProteomeXchange.

Title	Proteome characterization of Spleen during Schistosoma mansoni infection
Description	Schistosomiasis is a chronic parasitic disease that affects more that 230 million people worldwide. In the Americas, it caused by the blood flook Schistosoma mansoni. This parasite has a complex life cycle with two intermediary hosts. When infecting mammals, schistosomes cause an intense immune response to the presence of the different stages of the parasite within the host. After maturation of the worms and commencing of the oviposition, some eggs are transported via circulation to the liver, where they elicit an exaggerated inflammatory response in the tissue. This could lead to the formation of granulomas and liver fibrosis and along with this, the developent of hepatosplenomegaly and in the worst scenario could lead to the dead of the patient. In this project, we aim to make a shotgun evaluation of the proteome from splenocytes in a mice model, in order to identify novel molecular signatures associated with the immune respose to the presence of the parasite in the hosts.
HostingRepository	PRIDE
AnnounceDate	2019-02-13
AnnouncementXML	Submission_2019-02-13_06:07:03.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	William Borges
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2018-09-20 02:39:19	ID requested
⏵ 1	2019-02-13 06:07:04	announced

Cosenza-Contreras M, de Oliveira E Castro RA, Mattei B, Campos JM, Gon, ç, alves Silva G, de Paiva NCN, de Oliveira Aguiar-Soares RD, Carneiro CM, Afonso LCC, Castro-Borges W, The Schistosomiasis SpleenOME: Unveiling the Proteomic Landscape of Splenomegaly Using Label-Free Mass Spectrometry. Front Immunol, 9():3137(2018) [pubmed]

curator keyword: Biomedical

submitter keyword: Spleen, Schitosoma mansoni, immunology

William Castro Borges
contact affiliation	Departamento de Ciências Biológicas, Laboratório de Enzimologia e Proteômica, Instituto de Ciencias Ciências Exatas e Biológicas, Universidade Federal de Ouro Preto, Brasil
contact email	wborges@ufop.edu.br
lab head
William Borges
contact affiliation	Universidade Federal de Ouro Preto
contact email	wborges@ufop.edu.br
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/02/PXD011153

PRIDE project URI

• PRIDE
  1. PXD011153
     1. Label: PRIDE project
     2. Name: Proteome characterization of Spleen during Schistosoma mansoni infection