PXD011142

PXD011142 is an original dataset announced via ProteomeXchange.

Title	Multi-Omics Analyses Revealed Conserved Aging Signatures in Mice
Description	Studies on aging have largely included one or two OMICS layers, which may not necessarily reflect the signatures of other layers. Moreover, most aging studies have often compared very young (4-5 wks) mice with old (24 months) mice which does not reflect the aging transition after the attainment of adulthood. Therefore, we aimed to study and compared muti-OMICS aging signatures across key metabolic tissues of mature adults (6 months) and old (24 months) C57BL/6J mice (the most commonly used mouse strain). Here we compared the differentially regulated genes and enriched pathways for transcriptome, proteome and epigenome (H3K27ac, H3K4me3, H3K27me3, DNA methylation) across liver, heart, and quadriceps muscle. The major aging associated pathways cross multiple layers and tissues are decreased RNA metabolism, transcription, and translation at transcript and protein levels however increased potential of transcription at DNA methylation and H3K27ac levels.
HostingRepository	PRIDE
AnnounceDate	2021-11-30
AnnouncementXML	Submission_2021-11-30_12:15:59.502.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Evan Williams
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2018-09-19 03:02:50	ID requested
⏵ 1	2021-11-30 12:15:59	announced

Dataset with its publication pending

curator keyword: Biological

submitter keyword: Mouse tissue aging

Ruedi Aebersold
contact affiliation	Institue of Molecular Systems Biology ETH Zurich, Switzerland ( lab head ) (Alternate contact: Johan Auwerx, admin.auwerx@epfl.ch ; EPFL, Switzerland (lab head))
contact email	aebersold@imsb.ethz.ch
lab head
Evan Williams
contact affiliation	ETH Zurich
contact email	evan.williams@uni.lu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/11/PXD011142

PRIDE project URI

• PRIDE
  1. PXD011142
     1. Label: PRIDE project
     2. Name: Multi-Omics Analyses Revealed Conserved Aging Signatures in Mice