PXD011125

PXD011125 is an original dataset announced via ProteomeXchange.

Title	The interactome of a family of potential methyltransferases
Description	Human methytransferase like proteins (METTL) are part of a large protein family characterized by the presence of binding domains for S-adenosyl methionine, a co-substrate in most methylation reactions. Despite the fact that members of this protein family were shown or predicted to be DNA, RNA or protein methyltransferases, most METTL proteins are still poorly characterized. Identification of the complexes in which these potential enzymes act could help to understand their function(s) and substrate specificities. Here we systematically studied interacting partners of METTL protein family members using label-free quantitative mass spectrometry.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:14:54.964.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Pascal Jansen
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	protein modification; monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion ETD

Revision	Datetime	Status	ChangeLog Entry
0	2018-09-18 02:48:14	ID requested
1	2019-05-06 10:24:54	announced
⏵ 2	2024-10-22 04:14:58	announced	2024-10-22: Updated project metadata.

10.1038/s41598-019-43010-2;

Ignatova VV, Jansen PWTC, Baltissen MP, Vermeulen M, Schneider R, The interactome of a family of potential methyltransferases in HeLa cells. Sci Rep, 9(1):6584(2019) [pubmed]

curator keyword: Biological

submitter keyword: GFP affinity purifications, interaction proteomics, mass spectrometry,METTL

Robert Schneider
contact affiliation	Institute of Functional Epigenetics, Helmholtz Zentrum München, Deutsches Forschungszentrum fuer Gesundheit und Umwelt (GmbH) Ingolstaedter Landstr. 1, 85764, Neuherberg, Germany
contact email	robert.schneider@helmholtz-muenchen.de
lab head
Pascal Jansen
contact affiliation	Radboud University
contact email	p.jansen@science.ru.nl
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/05/PXD011125

PRIDE project URI

• PRIDE
  1. PXD011125
     1. Label: PRIDE project
     2. Name: The interactome of a family of potential methyltransferases