PXD011125 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | The interactome of a family of potential methyltransferases |
Description | Human methytransferase like proteins (METTL) are part of a large protein family characterized by the presence of binding domains for S-adenosyl methionine, a co-substrate in most methylation reactions. Despite the fact that members of this protein family were shown or predicted to be DNA, RNA or protein methyltransferases, most METTL proteins are still poorly characterized. Identification of the complexes in which these potential enzymes act could help to understand their function(s) and substrate specificities. Here we systematically studied interacting partners of METTL protein family members using label-free quantitative mass spectrometry. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_04:14:54.964.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Pascal Jansen |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | protein modification; monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue |
Instrument | Orbitrap Fusion ETD |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2018-09-18 02:48:14 | ID requested | |
1 | 2019-05-06 10:24:54 | announced | |
⏵ 2 | 2024-10-22 04:14:58 | announced | 2024-10-22: Updated project metadata. |
Publication List
10.1038/s41598-019-43010-2; |
Ignatova VV, Jansen PWTC, Baltissen MP, Vermeulen M, Schneider R, The interactome of a family of potential methyltransferases in HeLa cells. Sci Rep, 9(1):6584(2019) [pubmed] |
Keyword List
curator keyword: Biological |
submitter keyword: GFP affinity purifications, interaction proteomics, mass spectrometry,METTL |
Contact List
Robert Schneider |
contact affiliation | Institute of Functional Epigenetics, Helmholtz Zentrum München, Deutsches Forschungszentrum fuer Gesundheit und Umwelt (GmbH) Ingolstaedter Landstr. 1, 85764, Neuherberg, Germany |
contact email | robert.schneider@helmholtz-muenchen.de |
lab head | |
Pascal Jansen |
contact affiliation | Radboud University |
contact email | p.jansen@science.ru.nl |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD011125
- Label: PRIDE project
- Name: The interactome of a family of potential methyltransferases