PXD011119

PXD011119 is an original dataset announced via ProteomeXchange.

Title	Mouse Nedd4-2 and control with Pirfenidone
Description	Idiopathic pulmonary fibrosis (IPF) is a chronic progressive interstitial lung disease characterized by patchy scarring of the distal lung with limited therapeutic options and poor prognosis. Here, we show that conditional deletion of the ubiquitin ligase Nedd4-2 in lung epithelial cells in adult mice produces chronic lung disease that shares key features with IPF including progressive fibrosis and bronchiolization with increased expression of Muc5b in peripheral airways, honeycombing and characteristic alterations in the lung proteome.
HostingRepository	PRIDE
AnnounceDate	2020-03-20
AnnouncementXML	Submission_2020-04-28_22:15:55.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Alexander Gorol
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2018-09-18 02:02:16	ID requested
1	2020-03-20 00:01:55	announced
⏵ 2	2020-04-28 22:15:57	announced	2020-04-29: Updated publication reference for PubMed record(s): 32332792.

Duerr J, Leitz DHW, Szczygiel M, Dvornikov D, Fraumann SG, Kreutz C, Zadora PK, Seyhan Agircan A, Konietzke P, Engelmann TA, Hegermann J, Mulugeta S, Kawabe H, Knudsen L, Ochs M, Rotin D, Muley T, Kreuter M, Herth FJF, Wielp, ü, tz MO, Beers MF, Klingm, ü, ller U, Mall MA, Conditional deletion of Nedd4-2 in lung epithelial cells causes progressive pulmonary fibrosis in adult mice. Nat Commun, 11(1):2012(2020) [pubmed]

curator keyword: Biological, Biomedical

submitter keyword: Nedd4-2, Pirfenidone

Ursula Klingmüller
contact affiliation	Division Systems Biology of Signal Transduction, German Cancer Research Center (DKFZ), Heidelberg, Germany
contact email	u.klingmueller@dkfz.de
lab head
Alexander Gorol
contact affiliation	DKFZ Heidelberg
contact email	a.gorol@dkfz.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/03/PXD011119

PRIDE project URI

• PRIDE
  1. PXD011119
     1. Label: PRIDE project
     2. Name: Mouse Nedd4-2 and control with Pirfenidone