PXD011090

PXD011090 is an original dataset announced via ProteomeXchange.

Title	Sequential modulation of RNase III and RNase G expression in response to host environment conditions promotes pathogenicity through the control of hns expression in Salmonella Typhimurium
Description	Our results demonstrate that RNase G controls expression levels of H-NS encoded by hns, strongly associated with the pathogenicity of S. Typhimurium. The hns mRNA abundance is mediated by RNase G, which cleaves the 5’-UTR of hns mRNA. In the upstream pathway, the induced expression of RNase G in host environment condition is attributable to reduced RNase III cleavage activity on rng mRNA. Our findings suggest the link between Salmonella pathogenicity and RNase III-RNase G pathway, underlining the importance of posttranscriptional regulation of H-NS in the downstream pathway, which controls Salmonella pathogenicity island-1 type III secretion system for the survival and virulence of S. Typhimurium in host cell.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:17:35.144.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yong-Hak Kim
SpeciesList	scientific name: Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344; NCBI TaxID: 216597;
ModificationList	iodoacetamide derivatized residue
Instrument	ProteomeDiscoverer input parameter

Revision	Datetime	Status	ChangeLog Entry
0	2018-09-14 01:41:10	ID requested
1	2021-01-08 00:02:56	announced
⏵ 2	2024-10-22 05:17:35	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

ProteomeXchange project tag: Human Proteome Project

curator keyword: Biological, Biomedical

submitter keyword: Salmonella Typhimurium, gel-based LC-MSMS, type III secretion system effector proteins, bacterial culture supernatant

Yong-Hak Kim
contact affiliation	Daegu Catholic University School of Medicine
contact email	ykim@cu.ac.kr
lab head
Yong-Hak Kim
contact affiliation	Catholic University of Daegu School of Medicine
contact email	ykim@cu.ac.kr
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD011090
     1. Label: PRIDE project
     2. Name: Sequential modulation of RNase III and RNase G expression in response to host environment conditions promotes pathogenicity through the control of hns expression in Salmonella Typhimurium