PXD011044

PXD011044 is an original dataset announced via ProteomeXchange.

Title	PCNA-targeting peptide modifies and increases the response to EGFR/HER2/VEGF inhibition in breast cancer cells
Description	To combine inhibition of EGFR/HER2 and targeting of the cytosolic roles of PCNA using the APIM-peptide, and study the anti-cancer effects of this combinatory therapy in in vitro and in vivo breast cancer models.
HostingRepository	PRIDE
AnnounceDate	2020-01-17
AnnouncementXML	Submission_2020-01-17_05:59:10.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Animesh Sharma
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	acetylated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2018-09-10 03:11:41	ID requested
⏵ 1	2020-01-17 05:59:12	announced

S, ø, gaard CK, Nepal A, Petrovic V, Sharma A, Liabakk NB, Steigedal TS, Otterlei M, Targeting the non-canonical roles of PCNA modifies and increases the response to targeted anti-cancer therapy. Oncotarget, 10(68):7185-7197(2019) [pubmed]

curator keyword: Biomedical

submitter keyword: Combination therapy, multi-targeting therapy, signaling pathways, autophagy, HER2/ERBB2- human epidermal growth factor receptor 2, ER- estrogen receptor, PR- progesterone receptor, TNBC- triple negative breast cancer, VEGF- vascular endothelial growth factor, EGFR- epidermal growth factor receptor, MAPK- mitogen-activated protein kinase, PI3K- the phosphoinositide 3-kinase, PCNA- proliferating cell nuclear antigen

Marit Otterlei
contact affiliation	Professor Institutt for klinisk og molekylær medisin Norges teknisk-naturvitenskapelige universitet Erling Skjalgssons g 1, Laboratoriesenteret * 231.05.036 Trondheim 7030 Norway
contact email	marit.otterlei@ntnu.no
lab head
Animesh Sharma
contact affiliation	Engineer at NTNU, Norway
contact email	sharma.animesh@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/01/PXD011044

PRIDE project URI

• PRIDE
  1. PXD011044
     1. Label: PRIDE project
     2. Name: PCNA-targeting peptide modifies and increases the response to EGFR/HER2/VEGF inhibition in breast cancer cells