⮝ Full datasets listing

PXD010921

PXD010921 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleIdentification of CTPS1 Filament Interacting Proteins
DescriptionCTP synthase (CTPS) catalyzes the formation of CTP in de novo pyrimidine biosynthesis pathway. Compartmentalization of CTPS into filamentous structure is evolutionarily conserved from E.coli, yeast, Drosophila, mice to humans. Recently, we have demonstrated that histidine-mediated protein methylation promotes the formation of CTPS filament under glutamine and/or serum deprivation, which reduces its enzymatic activity and protects it from degradation. However, it is still unclear how the filament assembly takes place. In the current study, we used APEX2-mediated in vivo proximity labeling to identify proteins involved in CTPS filament formation.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_05:01:20.924.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterYu-Tsun Lin
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListiTRAQ4plex-116 reporter+balance reagent acylated residue; methylthiolated residue; monohydroxylated residue; acetylated residue
InstrumentLTQ Orbitrap Elite
Dataset History
RevisionDatetimeStatusChangeLog Entry
02018-08-29 03:24:02ID requested
12020-03-24 03:40:21announced
22024-10-22 05:01:21announced2024-10-22: Updated project metadata.
Publication List
10.1242/jcs.240200;
Chakraborty A, Lin WC, Lin YT, Huang KJ, Wang PY, Chang IY, Wang HI, Ma KT, Wang CY, Huang XR, Lee YH, Chen BC, Hsieh YJ, Chien KY, Lin TY, Liu JL, Sung LY, Yu JS, Chang YS, Pai LM, SNAP29 mediates the assembly of histidine-induced CTP synthase filaments in proximity to the cytokeratin network. J Cell Sci, 133(9):(2020) [pubmed]
Keyword List
curator keyword: Biological
submitter keyword: SNAP29, APEX2,CTPS, Cytokeratin
Contact List
Jau-Song Yu
contact affiliationMolecular Medicine Research Center, Chang Gung University, Taoyuan 33302, Taiwan
contact emailyusong@mail.cgu.edu.tw
lab head
Yu-Tsun Lin
contact affiliationChang Gung University
contact emaildoreenlin1230@gmail.com
dataset submitter
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/03/PXD010921
PRIDE project URI
Repository Record List
[ + ]