PXD010913

PXD010913 is an original dataset announced via ProteomeXchange.

Title	Integrated transcriptomics and proteomics analyses reveal anthelmintic mechanism of arctigenin against Gyrodactylus kobayashii
Description	The widespread resistance of parasitic worms to commonly used anthelmintics highlights the urgent need for development of new effective chemicals. Arctigenin (ARC) is a natural lignin compound that exhibits excellent anthelminthic efficacy against infections of Gyrodactylus, but knowledge about the mechanism of action is far from clear. In the present study, high-throughput RNA-sequencing was integrated with iTRAQ quantitative proteomics analysis to explore the anthelmintic mechanism and possible molecular targets of ARC against Gyrodactylus kobayashii.
HostingRepository	PRIDE
AnnounceDate	2020-05-26
AnnouncementXML	Submission_2020-05-26_12:13:53.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xiao Tu
SpeciesList	scientific name: Apis mellifera (Honeybee); NCBI TaxID: 7460; scientific name: Gyrodactylus kobayashii; NCBI TaxID: 89149;
ModificationList	iTRAQ8plex-116 reporter+balance reagent acylated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2018-08-28 08:44:05	ID requested
⏵ 1	2020-05-26 12:13:54	announced

Tu X, Tan X, Qi X, Huang A, Ling F, Wang G, Proteome interrogation using gold nanoprobes to identify targets of arctigenin in fish parasites. J Nanobiotechnology, 18(1):32(2020) [pubmed]

curator keyword: Biological

submitter keyword: Gyrodactylus;arctigenin;iTRAQ,target

Gaoxue Wang
contact affiliation	Northwest A&F University, College of Animal Science and Technology, Yangling,Shaanxi,China
contact email	wanggaoxue@126.com
lab head
Xiao Tu
contact affiliation	Northwest A&F University
contact email	tuxiao6613268@163.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD010913
     1. Label: PRIDE project
     2. Name: Integrated transcriptomics and proteomics analyses reveal anthelmintic mechanism of arctigenin against Gyrodactylus kobayashii