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PXD010902

PXD010902 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleRat white adipose tissue DIGE-LC-MSMS
DescriptionWhite adipose tissue is a central place to energy storage and a major endocrine organ. However, adipose molecular mechanisms have been poorly studied during prolonged fasting. To fill this gap, the aim of this study was to decipher proteomic regulations in rat adipose tissue during phase 2 (lipid mobilization) and phase 3 (protein catabolism) of prolonged fasting compared to the fed state. Specific responses reflecting adipose tissue inflammation, increased fibrinolysis and a possible protein catabolism-related energy saving mechanism were recorded during phase 3. Differences between internal and subcutaneous adipose tissues were essentially related to lipid metabolism, the response to oxidative stress and energy production. These data thus provide a molecular basis of adipose tissue responses according to the fasting stage.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_05:19:16.514.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterFabrice BERTILE
SpeciesList scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationListmonohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
InstrumentHCTplus
Dataset History
RevisionDatetimeStatusChangeLog Entry
02018-08-28 07:11:36ID requested
12021-02-24 01:07:16announced
22024-10-22 05:19:17announced2024-10-22: Updated project metadata.
Publication List
Ibrahim M, Ayoub D, Wasselin T, Van Dorsselaer A, Le Maho Y, Raclot T, Bertile F, Alterations in rat adipose tissue transcriptome and proteome in response to prolonged fasting. Biol Chem, 401(3):389-405(2020) [pubmed]
10.1515/hsz-2019-0184;
Keyword List
curator keyword: Biological
submitter keyword: LC-MSMS,Rat, fasting, white adipose tissue, 2D-DIGE
Contact List
Sarah Cianférani
contact affiliationLaboratoire de Spectrométrie de Masse BioOrganique, Analytical Science department, IPHC, CNRS, Strasbourg University, UMR7178, Strasbourg, France
contact emailsarah.cianferani@unistra.fr
lab head
Fabrice BERTILE
contact affiliationCNRS
contact emailfbertile@unistra.fr
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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