PXD010902 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Rat white adipose tissue DIGE-LC-MSMS |
Description | White adipose tissue is a central place to energy storage and a major endocrine organ. However, adipose molecular mechanisms have been poorly studied during prolonged fasting. To fill this gap, the aim of this study was to decipher proteomic regulations in rat adipose tissue during phase 2 (lipid mobilization) and phase 3 (protein catabolism) of prolonged fasting compared to the fed state. Specific responses reflecting adipose tissue inflammation, increased fibrinolysis and a possible protein catabolism-related energy saving mechanism were recorded during phase 3. Differences between internal and subcutaneous adipose tissues were essentially related to lipid metabolism, the response to oxidative stress and energy production. These data thus provide a molecular basis of adipose tissue responses according to the fasting stage. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_05:19:16.514.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Fabrice BERTILE |
SpeciesList | scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116; |
ModificationList | monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue |
Instrument | HCTplus |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2018-08-28 07:11:36 | ID requested | |
1 | 2021-02-24 01:07:16 | announced | |
⏵ 2 | 2024-10-22 05:19:17 | announced | 2024-10-22: Updated project metadata. |
Publication List
Ibrahim M, Ayoub D, Wasselin T, Van Dorsselaer A, Le Maho Y, Raclot T, Bertile F, Alterations in rat adipose tissue transcriptome and proteome in response to prolonged fasting. Biol Chem, 401(3):389-405(2020) [pubmed] |
10.1515/hsz-2019-0184; |
Keyword List
curator keyword: Biological |
submitter keyword: LC-MSMS,Rat, fasting, white adipose tissue, 2D-DIGE |
Contact List
Sarah Cianférani |
contact affiliation | Laboratoire de Spectrométrie de Masse BioOrganique, Analytical Science department, IPHC, CNRS, Strasbourg University, UMR7178, Strasbourg, France |
contact email | sarah.cianferani@unistra.fr |
lab head | |
Fabrice BERTILE |
contact affiliation | CNRS |
contact email | fbertile@unistra.fr |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD010902
- Label: PRIDE project
- Name: Rat white adipose tissue DIGE-LC-MSMS