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DataSet Summary

  • HostingRepository: PRIDE
  • AnnounceDate: 2019-01-11
  • AnnouncementXML: Submission_2019-01-11_02:00:08.xml
  • DigitalObjectIdentifier:
  • ReviewLevel: Peer-reviewed dataset
  • DatasetOrigin: Original data
  • RepositorySupport: Unsupported dataset by repository
  • PrimarySubmitter: Han Hu
  • Title: Honeybee hypopharyngeal glands LC-MS/MS
  • Description: Royal jelly (RJ) is a proteinaceous secretion of the hypopharyngeal glands (HGs) in the head of honeybee workers. It is a critical food for queen bees and young larvae that decides the fate of fertilized eggs in developing into either queen bees or worker bees during the early larval stages. RJ is also widely used in humans for health promotion as agent, such as antibacterial, antioxidant, and antiaging properties. To increase RJ yields, a stock of high RJ producing honeybees (RJBs) has genetically selected from Italian honeybees (ITBs) in China since 1980s. To date, one colony of RJBs can produce more than 10 kg of RJ per year, a yield that is 10-times greater than that produced by a colony of ITBs. To elucidate the mechanism of the enforced gland performance in producing RJ in RJBs, the spatio-temporal HG proteomes of newly emerged bees, nurse bees, and forager bees, were compared between the ITBs and RJBs. Proteins in the critical pathways that are implicated in the secretory activity of RJ in HGs are validated biochemically and biologically by manipulating the NBs into extended nursing periods and the FBs to revert into NBs. This will provide a novel mechanistic insight into the HGs achieving an enhanced biological mission of producing the valuable bee-product, RJ.
  • SpeciesList: scientific name: Apis mellifera (Honeybee); NCBI TaxID: 7460;
  • ModificationList: monohydroxylated residue; iodoacetamide derivatized residue
  • Instrument: Q Exactive

Dataset History

VersionDatetimeStatusChangeLog Entry
02018-08-28 05:31:49ID requested
12019-01-11 02:00:09announced

Publication List

  1. Hu H, Bezabih G, Feng M, Wei Q, Zhang X, Wu F, Meng L, Fang Y, Han B, Ma C, Li J, In-depth Proteome of the Hypopharyngeal Glands of Honeybee Workers Reveals Highly Activated Protein and Energy Metabolism in Priming the Secretion of Royal Jelly. Mol Cell Proteomics, 18(4):606-621(2019) [pubmed]

Keyword List

  1. curator keyword: Biological
  2. submitter keyword: Honeybee, Hypopharyngeal glands, High royal jelly producing bees,

Contact List

    Jianke Li
    • contact affiliation: Institute of Apicultural Research, Chinese Academy of Agricultural Sciences, No. 1 Beigou Xiangshan, Beijing, 100193, China
    • contact email: apislijk@163.com
    • lab head:
    Han Hu
    • contact affiliation: Chinese Academy of Agricultural Sciences, Institute of Apicultural Research
    • contact email: wuhan_hh@126.com
    • dataset submitter:

Full Dataset Link List

  1. Dataset FTP location
  2. PRIDE project URI
Repository Record List

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