PXD010852 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Connective tissue regeneration dynamics persistently alter epithelial dynein DNAH10 expression - DNAH10 overexpression in psoriatic lesional epidermis |
Description | The objective of this study was to investigate how active dermal connective tissue composition dynamics affect long term protein expression in the epidermis. After surgically removing damaged skin to its full thickness at the site of a deep burn in ten patients, we randomized three adjacent test areas within the wounds to receive either: 1) no dermal component as control, 2) a permanent artificial dermal matrix or 3) a temporary dressing to induce formation of granulation tissue. Each area was then covered with an autologous superficial healty skin transplant as the epidermal indicator. One year later, biopsy samples were taken from each site. The epidermis and dermis were selectively microdissected by laser-capture from cut tissue biopsy sections, and analyzed using untargeted non-labelled quantitative proteomics. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_05:04:48.984.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Mariliis Klaas |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | acetylated residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2018-08-23 06:55:00 | ID requested | |
1 | 2020-05-26 12:17:50 | announced | |
⏵ 2 | 2024-10-22 05:04:52 | announced | 2024-10-22: Updated project metadata. |
Publication List
Lagus H, Klaas M, Juteau S, Elomaa O, Kere J, Vuola J, Jaks V, Kankuri E, Discovery of increased epidermal DNAH10 expression after regeneration of dermis in a randomized with-in person trial - reflections on psoriatic inflammation. Sci Rep, 9(1):19136(2019) [pubmed] |
10.1038/s41598-019-53874-z; |
Keyword List
curator keyword: Technical, Biological |
submitter keyword: Human, skin, dermis, burn injury, label-free quantification, epidermis |
Contact List
Esko Kankuri |
contact affiliation | Faculty of Medicine, Department of Pharmacology, University of Helsinki, Finland |
contact email | esko.kankuri@helsinki.fi |
lab head | |
Mariliis Klaas |
contact affiliation | University of Tartu |
contact email | mariliis.klaas@ut.ee |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/05/PXD010852 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD010852
- Label: PRIDE project
- Name: Connective tissue regeneration dynamics persistently alter epithelial dynein DNAH10 expression - DNAH10 overexpression in psoriatic lesional epidermis