PXD010852

PXD010852 is an original dataset announced via ProteomeXchange.

Title	Connective tissue regeneration dynamics persistently alter epithelial dynein DNAH10 expression - DNAH10 overexpression in psoriatic lesional epidermis
Description	The objective of this study was to investigate how active dermal connective tissue composition dynamics affect long term protein expression in the epidermis. After surgically removing damaged skin to its full thickness at the site of a deep burn in ten patients, we randomized three adjacent test areas within the wounds to receive either: 1) no dermal component as control, 2) a permanent artificial dermal matrix or 3) a temporary dressing to induce formation of granulation tissue. Each area was then covered with an autologous superficial healty skin transplant as the epidermal indicator. One year later, biopsy samples were taken from each site. The epidermis and dermis were selectively microdissected by laser-capture from cut tissue biopsy sections, and analyzed using untargeted non-labelled quantitative proteomics.
HostingRepository	PRIDE
AnnounceDate	2020-05-26
AnnouncementXML	Submission_2020-05-26_12:17:49.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Mariliis Klaas
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2018-08-23 06:55:00	ID requested
⏵ 1	2020-05-26 12:17:50	announced

Lagus H, Klaas M, Juteau S, Elomaa O, Kere J, Vuola J, Jaks V, Kankuri E, Discovery of increased epidermal DNAH10 expression after regeneration of dermis in a randomized with-in person trial - reflections on psoriatic inflammation. Sci Rep, 9(1):19136(2019) [pubmed]

curator keyword: Technical, Biological

submitter keyword: Human, skin, epidermis, dermis, label-free quantification, burn injury

Esko Kankuri
contact affiliation	Faculty of Medicine, Department of Pharmacology, University of Helsinki, Finland
contact email	esko.kankuri@helsinki.fi
lab head
Mariliis Klaas
contact affiliation	University of Tartu
contact email	mariliis.klaas@ut.ee
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/05/PXD010852

PRIDE project URI

• PRIDE
  1. PXD010852
     1. Label: PRIDE project
     2. Name: Connective tissue regeneration dynamics persistently alter epithelial dynein DNAH10 expression - DNAH10 overexpression in psoriatic lesional epidermis