PXD010818
PXD010818 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Liver Proteomics of the Hybrid Mouse Diversity Panel |
Description | Hepatosteatosis underlies several diseases including type 2 diabetes, cardiovascular disease and liver disease. Unfortunately, our understanding of the contributing pathways that initiate and advance hepatosteatosis to subsequent complications is still poorly understood. Here, we take advantage of recent developments in “omics” technologies to perform high resolution proteomics (>5000 proteins) and quantitative lipidomics (>300 lipids) on livers from 107 genetically diverse inbred mouse strains from the hybrid mouse diversity panel. Integration of these data allowed us to define novel regulators of lipid metabolism in the liver. |
HostingRepository | PRIDE |
AnnounceDate | 2019-03-05 |
AnnouncementXML | Submission_2019-03-05_07:19:50.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Benjamin Parker |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | TMT6plex-126 reporter+balance reagent acylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2018-08-20 02:08:48 | ID requested | |
⏵ 1 | 2019-03-05 07:19:52 | announced |
Publication List
Parker BL, Calkin AC, Seldin MM, Keating MF, Tarling EJ, Yang P, Moody SC, Liu Y, Zerenturk EJ, Needham EJ, Miller ML, Clifford BL, Morand P, Watt MJ, Meex RCR, Peng KY, Lee R, Jayawardana K, Pan C, Mellett NA, Weir JM, Lazarus R, Lusis AJ, Meikle PJ, James DE, de Aguiar Vallim TQ, Drew BG, An integrative systems genetic analysis of mammalian lipid metabolism. Nature, 567(7747):187-193(2019) [pubmed] |
Keyword List
ProteomeXchange project tag: Liver (B/D-HPP) |
curator keyword: Biological, Biomedical |
submitter keyword: liver, hybrid mouse diversity panel |
Contact List
Benjamin Parker | |
---|---|
contact affiliation | The University of Sydney |
contact email | benjamin.parker@sydney.edu.au |
lab head | |
Benjamin Parker | |
contact affiliation | The University of Sydney |
contact email | benjamin.parker@sydney.edu.au |
dataset submitter |
Full Dataset Link List
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/03/PXD010818 |
PRIDE project URI |
Repository Record List
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