PXD010798

PXD010798 is an original dataset announced via ProteomeXchange.

Title	Oral Pathogen ‘Neutralizes’ the Human Innate Immune Defence
Description	Our present findings show for the first time that the virulence factor PPAD protects the oral pathogen P. gingivalis against neutrophil insults at three distinct levels, namely phagocytosis, NETosis and CAMP activity. This identifies PPAD as a major agent in the evasion of human innate immunity, a view that is supported by studies from Potempa and co-workers showing PPAD-dependent citrullination of complement29. Why is this important? Every day, millions of people lose teeth due to periodontitis. This has a serious impact on their quality of life, not only for aesthetic reasons but much more so because tooth loss causes difficulties in eating and interferes with interpersonal communication. Yet, only few people realize that there is a major bacteriological component in periodontitis where our immune defences are breached with potentially serious implications, especially systemic and chronic diseases ranging from bacteraemia to rheumatoid arthritis.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:47:58.907.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Thomas Sura
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue; deamidated residue
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2018-08-16 03:44:36	ID requested
1	2018-10-15 01:12:35	announced
2	2018-12-04 03:58:33	announced	Updated project metadata.
⏵ 3	2024-10-22 04:47:59	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

curator keyword: Biological, Biomedical

submitter keyword: Human, Neutrophils, P. gingivalis, PPAD, LC-MS/MS

Doerte Becher
contact affiliation	Uni Greifswald Hausdorffstrasse 8 17489 Greifswald Germany; Institute for Microbiology; Department of Microbial Proteomics
contact email	dbecher@uni-greifswald.de
lab head
Thomas Sura
contact affiliation	University of Greifswald, Center for Functional Genomics of Microbes, Institute of Microbiology, Department of Microbial Proteomics
contact email	thomas.sura@uni-greifswald.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/10/PXD010798

PRIDE project URI

• PRIDE
  1. PXD010798
     1. Label: PRIDE project
     2. Name: Oral Pathogen ‘Neutralizes’ the Human Innate Immune Defence