PXD010737

PXD010737 is an original dataset announced via ProteomeXchange.

Title	β-TrCP and Casein Kinase II mediated degradation of cyclin F controls timely mitotic progression
Description	Orderly progressions of events in the cell division cycle are necessary to ensure the replication of DNA and cell division. Checkpoint systems allow the accurate execution of each cell cycle phase. The precise regulation of the levels of cyclin proteins is fundamental to coordinate cell division with checkpoints, avoiding genome instability. Cyclin F has important functions in regulating the cell cycle during the G2 checkpoint; however, the mechanisms underlying the regulation of cyclin F are poorly understood. Here, we observe that cyclin F is regulated by proteolysis through β-TrCP. β-TrCP recognizes cyclin F through a non-canonical degron site (TSGXXS) after its phosphorylation by Casein Kinase II. The degradation of cyclin F mediated by β-TrCP occurs at the G2/M transition and this event is required to promote mitotic progression and favours the activation of a transcriptional programme required for mitosis.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:47:52.543.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD010737
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Roman Fischer
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	Phospho; Deamidated; Oxidation; Carbamidomethyl
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2018-08-09 02:58:26	ID requested
1	2018-10-02 06:14:18	announced
2	2018-12-04 03:57:30	announced	Updated project metadata.
3	2019-02-07 03:50:21	announced	Updated project metadata.
⏵ 4	2024-10-22 04:47:58	announced	2024-10-22: Updated project metadata.

10.1016/j.celrep.2018.08.076;

Mavrommati I, Faedda R, Galasso G, Li J, Burdova K, Fischer R, Kessler BM, Carrero ZI, Guardavaccaro D, Pagano M, D'Angiolella V, -TrCP- and Casein Kinase II-Mediated Degradation of Cyclin F Controls Timely Mitotic Progression. Cell Rep, 24(13):3404-3412(2018) [pubmed]

10.6019/PXD010737;

curator keyword: Biological

submitter keyword: mitotic progression,CK2, Cyclin F

Roman Fischer
contact affiliation	Discovery Proteomics Facility, Target Discovery Institute, University of Oxford
contact email	roman.fischer@ndm.ox.ac.uk
lab head
Roman Fischer
contact affiliation	University of Oxford
contact email	roman.fischer@ndm.ox.ac.uk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/10/PXD010737

PRIDE project URI

• PRIDE
  1. PXD010737
     1. Label: PRIDE project
     2. Name: β-TrCP and Casein Kinase II mediated degradation of cyclin F controls timely mitotic progression