PXD010631

PXD010631 is an original dataset announced via ProteomeXchange.

Title	Partial covariance two-dimensional mass spectrometry for bio-molecular primary structure
Description	A new kind of two-dimensional mass spectrometry is described and applied to peptides, proteins and oligonucleotides. Partial covariance two-dimensional mass spectrometry (pC-2DMS) detects intrinsic statistical correlations between bio-molecular fragments originating from the same or consecutive decomposition events. This enables the identification of pairs of ions sharing a common origin across the entire fragment mass spectrum. The fragment-fragment correlations revealed by pC-2DMS are much more specific to the bio-molecular primary structure and its modifications than the individual fragment mass-to-charge ratios on which standard one-dimensional mass spectrometry (MS) is based. We illustrate the analytical power of pC-2DMS by demonstrating the identification of mixtures of combinatorial post-translational modification patterns inaccessible to standard MS.
HostingRepository	PRIDE
AnnounceDate	2023-09-30
AnnouncementXML	Submission_2023-09-30_04:16:11.669.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	TaranDriver
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	3'-nitro-L-tyrosine; acetylated residue; dimethylated residue
Instrument	LTQ

Revision	Datetime	Status	ChangeLog Entry
0	2018-07-31 06:19:56	ID requested
⏵ 1	2023-09-30 04:16:12	announced

Dataset with its publication pending

curator keyword: Technical

submitter keyword: two-dimensional, combinatorial modifications

MarinaEdelson-Averbukh
contact affiliation	Imperial College London, UK
contact email	m.edelson-averbukh@imperial.ac.uk
lab head
TaranDriver
contact affiliation	Imperial College London
contact email	t.driver14@imperial.ac.uk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/09/PXD010631

PRIDE project URI

• PRIDE
  1. PXD010631
     1. Label: PRIDE project
     2. Name: Partial covariance two-dimensional mass spectrometry for bio-molecular primary structure