PXD010614

PXD010614 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Structure-Activity Relationships of ENMs
Description	Current nano-SARs are often based on univariate assessments and fail to provide tiered views on ENM-induced bio-effects. Here we pioneered a multi-hierarchical nano-SAR assessment for a representative ENM, Fe2O3, by metabolomics and proteomics analyses. The established nano-SAR profile allows visualizing the contributions of 7 basic properties of Fe2O3 to its diverse bio-effects. For instance, while surface reactivity is responsible for Fe2O3-induced cell migration, the inflammatory effects of Fe2O3 are determined by aspect ratio (nanorods) or surface reactivity (nanoplates). These nano-SARs were examined in THP-1 cells and animal lungs, which allowed us to decipher the detailed mechanisms including NLRP3 inflammasome pathway and monocyte chemoattractant protein-1 dependent signaling. This study provides new insights for nano-SARs, which may facilitate the tailored design of ENMs to endow them with desired bio-effects.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:48:01.860.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xiaoming Cai
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; acetylated residue
Instrument	LTQ Orbitrap

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2018-07-30 03:38:04	ID requested
1	2019-11-12 13:03:02	announced
⏵ 2	2024-10-22 04:48:02	announced	2024-10-22: Updated project metadata.

Publication List

Cai X, Dong J, Liu J, Zheng H, Kaweeteerawat C, Wang F, Ji Z, Li R, Multi-hierarchical profiling the structure-activity relationships of engineered nanomaterials at nano-bio interfaces. Nat Commun, 9(1):4416(2018) [pubmed]
10.1038/s41467-018-06869-9;

Cai X, Dong J, Liu J, Zheng H, Kaweeteerawat C, Wang F, Ji Z, Li R, Multi-hierarchical profiling the structure-activity relationships of engineered nanomaterials at nano-bio interfaces. Nat Commun, 9(1):4416(2018) [pubmed]

10.1038/s41467-018-06869-9;

Keyword List

curator keyword: Biological
submitter keyword: proteomics, metabolomics, SAR,ENMs

curator keyword: Biological

submitter keyword: proteomics, metabolomics, SAR,ENMs

Contact List

Xiaoming cai
contact affiliation	Soochow University
contact email	xiaomingcai1982@hotmail.com
lab head
Xiaoming Cai
contact affiliation	Soochow University
contact email	xiaomingcai1982@hotmail.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/11/PXD010614
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/11/PXD010614

PRIDE project URI

Repository Record List

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