PXD010608

PXD010608 is an original dataset announced via ProteomeXchange.

Title	Plasma Proteome Dynamics in the Pig Model of Trauma
Description	The effect of IV-adminstered Vitamin C on the plasma proteome in the pig trauma model was investigated with label free proteomics. Plasma samples were drawn from 9 male Sinclair swine at baseline, post-trauma, and 0.25, 2, and 4 hourspost resuscitation with 500 mL of hydroxyethyl starch. Swine were randomized to receive either saline, low-dose VitC (50 mg/kg), or high-dose VitC (200 mg/kg) during volume resuscitation (N = 3/treatment). High performance LC-MS/MS proteomics was then used to quantitatively measure plasma protein fluctations over time as a function of treatment.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:49:38.999.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Adam Hawkridge
SpeciesList	scientific name: Sus scrofa domesticus (domestic pig); NCBI TaxID: 9825;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue; deamidated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2018-07-30 02:09:54	ID requested
1	2022-03-10 17:52:05	announced
⏵ 2	2023-11-14 08:49:41	announced	2023-11-14: Updated project metadata.

Cudjoe EK, Hassan ZH, Kang L, Reynolds PS, Fisher BJ, McCarter J, Sweeney C, Martin EJ, Middleton P, Ellenberg M, Fowler AA, Spiess BD, Brophy DF, Hawkridge AM, Natarajan R, Temporal map of the pig polytrauma plasma proteome with fluid resuscitation and intravenous vitamin C treatment. J Thromb Haemost, 17(11):1827-1837(2019) [pubmed]

curator keyword: Biomedical

submitter keyword: ADAMTS13, Vitamin C, Plasma, VWF, Proteomics,Trauma

Adam Hawkridge
contact affiliation	Department of Pharmaceutics and Pharmacotherapy
contact email	amhawkridge@vcu.edu
lab head
Adam Hawkridge
contact affiliation	Virginia Commonwealth University
contact email	amhawkridge@vcu.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/03/PXD010608

PRIDE project URI

• PRIDE
  1. PXD010608
     1. Label: PRIDE project
     2. Name: Plasma Proteome Dynamics in the Pig Model of Trauma