PXD010589

PXD010589 is an original dataset announced via ProteomeXchange.

Title	EndoC-betaH3 Cell FANCA Protein Interactions Regulated by Glucose Stimulation
Description	Hyperinsulinemia affects 72% of Fanconi anemia (FA) patients and an additional 25% experience lowered glucose tolerance or frank diabetes. The underlying molecular mechanisms contributing to the dysfunction of FA pancreas β cells is unknown. Therefore, we sought to identify previously unexplored roles of FA proteins in the glucose responsive human pancreas β cell line EndoC-βH3 using a mass spectrometry-based protein interaction analysis of endogenous FANCA. This study reveals glucose stimulation-dependent changes in the FANCA interaction network indicative of the DNA damage response (DDR) through interactions with other FA proteins. We identify protein interactions with FANCA related to β cell insulin secretion.
HostingRepository	PRIDE
AnnounceDate	2019-07-25
AnnouncementXML	Submission_2019-09-02_00:05:13.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD010589
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Nicholas Woods
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	Ammonia-loss; Phospho; Dehydrated; Oxidation; Acetyl; Carbamidomethyl
Instrument	Orbitrap Fusion Lumos; Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2018-07-27 01:58:31	ID requested
1	2019-07-25 07:08:29	announced
⏵ 2	2019-09-02 00:05:14	announced	Updated publication reference for PubMed record(s): 31461451.

Lagund, ž, in D, Hu WF, Law HCH, Krieger KL, Qiao F, Clement EJ, Drincic AT, Nedi, ć O, Naldrett MJ, Alvarez S, Woods NT, cells through its protein interactome. PLoS One, 14(8):e0220568(2019) [pubmed]

ProteomeXchange project tag: Diabetes (B/D-HPP)

curator keyword: Biological

submitter keyword: Human, Pancreas Beta Cell, Glucose Stimulation

Nicholas T. Woods
contact affiliation	Eppley Institute for Research in Cancer University of Nebraska Medical Center Omaha, NE 68198, USA
contact email	nicholas.woods@unmc.edu
lab head
Nicholas Woods
contact affiliation	University of Nebraska Medical Center - Eppley Institute for Research in Cancer
contact email	Nicholas.Woods@unmc.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/07/PXD010589

PRIDE project URI

• PRIDE
  1. PXD010589
     1. Label: PRIDE project
     2. Name: EndoC-betaH3 Cell FANCA Protein Interactions Regulated by Glucose Stimulation