PXD010574

PXD010574 is an original dataset announced via ProteomeXchange.

Title	Human HER2-breast cancer cell line, trastuzumab-resistant, LC-MSMS
Description	We established an acquired trastuzumab-resistant model in vitro from a trastuzumab-sensitive, HER2-amplified breast-cancer cell line. A multi-omic strategy was implemented to obtain gene, proteome, and phosphoproteome signatures associated with acquired resistance to trastuzumab in HER2-positive breast cancer, followed by validation in human clinical samples.
HostingRepository	PRIDE
AnnounceDate	2020-06-01
AnnouncementXML	Submission_2020-06-01_03:26:22.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	JUAN MADOZ
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue; 6x(13)C labeled residue; monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2018-07-26 03:40:44	ID requested
⏵ 1	2020-06-01 03:26:23	announced

Gonz, á, lez-Alonso P, Zazo S, Mart, í, n-Aparicio E, Luque M, Chamizo C, Sanz-, Á, lvarez M, Minguez P, G, ó, mez-L, ó, pez G, Crist, ó, bal I, Caram, é, s C, Garc, í, a-Foncillas J, Eroles P, Lluch A, Arp, í O, Rovira A, Albanell J, Piersma SR, Jimenez CR, Madoz-G, ú, rpide J, Rojo F, The Hippo Pathway Transducers YAP1/TEAD Induce Acquired Resistance to Trastuzumab in HER2-Positive Breast Cancer. Cancers (Basel), 12(5):(2020) [pubmed]

ProteomeXchange project tag: Cancer (B/D-HPP)

submitter keyword: Human, breast cancer, SILAC, LC-MSMS

Juan Madoz-Gurpide
contact affiliation	Cancer Biomarkers Research Group Health Research Institute-Fundacion Jimenez Diaz (IIS-FJD, UAM) Madrid, Spain
contact email	JMadoz@fdj.es
lab head
JUAN MADOZ
contact affiliation	IIS-FJD
contact email	JMadoz@fjd.es
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/06/PXD010574

PRIDE project URI

• PRIDE
  1. PXD010574
     1. Label: PRIDE project
     2. Name: Human HER2-breast cancer cell line, trastuzumab-resistant, LC-MSMS