PXD010570

PXD010570 is an original dataset announced via ProteomeXchange.

Title	293FT Cell Endogenous FANCA Protein-Protein Interactions
Description	Hyperinsulinemia affects 72% of Fanconi anemia (FA) patients and an additional 25% experience lowered glucose tolerance or frank diabetes. The underlying molecular mechanisms contributing to the dysfunction of FA pancreas β cells is unknown. These experiments were performed in 293FT HEK cells as a part of the optimization and validation of the endogenous IP and to establish the FANCA interactome in a non-pancreas cell line to delineate beta cell-specific FANCA interactions.
HostingRepository	PRIDE
AnnounceDate	2019-07-25
AnnouncementXML	Submission_2019-09-02_00:05:24.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD010570
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Nicholas Woods
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	Ammonia-loss; Phospho; Dehydrated; Oxidation; Acetyl; Carbamidomethyl
Instrument	LTQ Orbitrap Velos; Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2018-07-26 02:32:07	ID requested
1	2019-07-25 06:46:39	announced
⏵ 2	2019-09-02 00:05:25	announced	Updated publication reference for PubMed record(s): 31461451.

Lagund, ž, in D, Hu WF, Law HCH, Krieger KL, Qiao F, Clement EJ, Drincic AT, Nedi, ć O, Naldrett MJ, Alvarez S, Woods NT, cells through its protein interactome. PLoS One, 14(8):e0220568(2019) [pubmed]

curator keyword: Biomedical

submitter keyword: Fanconi Anemia Complementation Group A, FANCA, Protein-Protein Interaction

Nicholas T. Woods, Ph.D.
contact affiliation	Eppley Institute for Research in Cancer University of Nebraska Medical Center Omaha, NE 68198, USA
contact email	nicholas.woods@unmc.edu
lab head
Nicholas Woods
contact affiliation	University of Nebraska Medical Center - Eppley Institute for Research in Cancer
contact email	Nicholas.Woods@unmc.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/07/PXD010570

PRIDE project URI

• PRIDE
  1. PXD010570
     1. Label: PRIDE project
     2. Name: 293FT Cell Endogenous FANCA Protein-Protein Interactions