PXD010558

PXD010558 is an original dataset announced via ProteomeXchange.

Title	Protein Deacetylase CobB Interplays with c-di-GMP
Description	As a ubiquitous bacterial secondary messenger, c-di-GMP plays key regulatory roles in processes like bacterial motility and transcription regulation. We found that c-di-GMP had impact on lysine acetylation level. To further investigate the regulation role, we performed a quantitative analysis of E. coli acetylome. In addition, we found that CobB is an effective deacetylase of YdeH, a major diguanylate cyclase (DGC) of E.coli that is endogenously acetylated. Mass spectrometry analysis identified YdeH K4 as the major site of acetylation, and it could be deacetylated by CobB.
HostingRepository	PRIDE
AnnounceDate	2019-06-17
AnnouncementXML	Submission_2019-08-20_07:09:27.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Zhaowei Xu
SpeciesList	scientific name: Escherichia coli; NCBI TaxID: 562;
ModificationList	acetylated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2018-07-25 03:12:29	ID requested
1	2019-06-17 03:18:14	announced
⏵ 2	2019-08-20 07:09:28	announced	Updated publication reference for PubMed record(s): 31418899.

Xu Z, Zhang H, Zhang X, Jiang H, Liu C, Wu F, Qian L, Hao B, Czajkowsky DM, Guo S, Xu Z, Bi L, Wang S, Li H, Tan M, Yan W, Feng L, Hou J, Tao SC, Interplay between the bacterial protein deacetylase CobB and the second messenger c-di-GMP. EMBO J, 38(18):e100948(2019) [pubmed]

curator keyword: Biological

submitter keyword: Acetylation, c-di-GMP, YdeH

Zhaowei Xu
contact affiliation	Shanghai Jiao Tong University
contact email	xuzhaowei-lu@sjtu.edu.cn
lab head
Zhaowei Xu
contact affiliation	Shanghai Jiaotong University
contact email	xuzhaowei-lu@sjtu.edu.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/06/PXD010558

PRIDE project URI

• PRIDE
  1. PXD010558
     1. Label: PRIDE project
     2. Name: Protein Deacetylase CobB Interplays with c-di-GMP