PXD010471 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Background Proteins in Human Chorionic Gonadotrophin Pharmaceutical Formulations of Different Origin |
Description | Gonadotrophins, including Human chorionic gonadotrophin (hCG), have been used since and for several decades to treat infertility by ovarian stimulation. The hCG is being extracted from urine of pregnant women and it does inevitably contains other proteins secreted into urine. The presence of other proteins varies from batch to batch and it can be significantly high. Current study investigated the presence of proteins other than hCG in different batches of commercial formulations produced by extraction from urine and by using the recombinant approach. The total protein content varied from batch to batch and a large number of contaminant urinary proteins were identified in all analyzed samples except for the recombinant product |
HostingRepository | PRIDE |
AnnounceDate | 2019-03-21 |
AnnouncementXML | Submission_2019-03-21_07:29:39.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD010471 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Goran Mitulović |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | Phospho; Oxidation; Carbamidomethyl |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2018-07-18 02:37:40 | ID requested | |
⏵ 1 | 2019-03-21 07:29:40 | announced | |
Publication List
Pani, ć, -Jankovi, ć T, Mitulovi, ć G, Human chorionic gonadotrophin pharmaceutical formulations of urinary origin display high levels of contaminant proteins-A label-free quantitation proteomics study. Electrophoresis, 40(11):1622-1629(2019) [pubmed] |
Keyword List
curator keyword: Biomedical |
submitter keyword: in-vitro fertilization, contaminants, urine, gonadotrophin |
Contact List
Goran Mitulović |
contact affiliation | Medical University of Vienna, Proteomics Core Facility and Clinical Department of Laboratory Medicine |
contact email | goran.mitulovic@meduniwien.ac.at |
lab head | |
Goran Mitulović |
contact affiliation | Medizinische Universität Wien |
contact email | goran.mitulovic@meduniwien.ac.at |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD010471
- Label: PRIDE project
- Name: Background Proteins in Human Chorionic Gonadotrophin Pharmaceutical Formulations of Different Origin