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PXD010471

PXD010471 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleBackground Proteins in Human Chorionic Gonadotrophin Pharmaceutical Formulations of Different Origin
DescriptionGonadotrophins, including Human chorionic gonadotrophin (hCG), have been used since and for several decades to treat infertility by ovarian stimulation. The hCG is being extracted from urine of pregnant women and it does inevitably contains other proteins secreted into urine. The presence of other proteins varies from batch to batch and it can be significantly high. Current study investigated the presence of proteins other than hCG in different batches of commercial formulations produced by extraction from urine and by using the recombinant approach. The total protein content varied from batch to batch and a large number of contaminant urinary proteins were identified in all analyzed samples except for the recombinant product
HostingRepositoryPRIDE
AnnounceDate2019-03-21
AnnouncementXMLSubmission_2019-03-21_07:29:39.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD010471
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterGoran Mitulović
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListPhospho; Oxidation; Carbamidomethyl
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02018-07-18 02:37:40ID requested
12019-03-21 07:29:40announced
Publication List
Pani, ć, -Jankovi, ć T, Mitulovi, ć G, Human chorionic gonadotrophin pharmaceutical formulations of urinary origin display high levels of contaminant proteins-A label-free quantitation proteomics study. Electrophoresis, 40(11):1622-1629(2019) [pubmed]
Keyword List
curator keyword: Biomedical
submitter keyword: in-vitro fertilization, contaminants, urine, gonadotrophin
Contact List
Goran Mitulović
contact affiliationMedical University of Vienna, Proteomics Core Facility and Clinical Department of Laboratory Medicine
contact emailgoran.mitulovic@meduniwien.ac.at
lab head
Goran Mitulović
contact affiliationMedizinische Universität Wien
contact emailgoran.mitulovic@meduniwien.ac.at
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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