PXD010421 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | The beta-catenin interactome in a vascular smooth muscle cell model |
Description | Canonical Wnt/β-catenin signalling is an essential regulator of various cellular functions throughout development and adulthood. Aberrant Wnt/β-catenin signalling also contributes to various pathologies including cancer, necessitating an understanding of cell context dependent mechanisms regulating this pathway. Since protein-protein interactions underpin β-catenin function and localization, we sought to identify novel β-catenin interacting partners by affinity purification coupled with tandem mass spectrometry in vascular smooth muscle cells (VSMCs), where β-catenin is involved in both physiological and pathological control of cell proliferation. Here, we report novel components of the VSMC β-catenin interactome. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_04:46:28.696.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Declan Williams |
SpeciesList | scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116; |
ModificationList | dihydroxylated residue; phosphorylated residue; monohydroxylated residue; iodoacetamide derivatized residue; deamidated residue |
Instrument | LTQ Orbitrap Elite |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2018-07-13 03:19:00 | ID requested | |
1 | 2018-10-25 09:09:56 | announced | |
2 | 2018-12-04 03:52:04 | announced | Updated project metadata. |
⏵ 3 | 2024-10-22 04:46:29 | announced | 2024-10-22: Updated project metadata. |
Publication List
Dataset with its publication pending |
Keyword List
curator keyword: Biological, Biomedical |
submitter keyword: vascular smooth muscle cell, rat,Aorta, interactome, beta-catenin, LC-MS/MS |
Contact List
John C. McDermott |
contact affiliation | Department of Biology, York University, Toronto, Ontario, Canada |
contact email | jmcderm@yorku.ca |
lab head | |
Declan Williams |
contact affiliation | University of Toronto |
contact email | gwillym.williams@utoronto.ca |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/10/PXD010421 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD010421
- Label: PRIDE project
- Name: The beta-catenin interactome in a vascular smooth muscle cell model