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PXD010421

PXD010421 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleThe beta-catenin interactome in a vascular smooth muscle cell model
DescriptionCanonical Wnt/β-catenin signalling is an essential regulator of various cellular functions throughout development and adulthood. Aberrant Wnt/β-catenin signalling also contributes to various pathologies including cancer, necessitating an understanding of cell context dependent mechanisms regulating this pathway. Since protein-protein interactions underpin β-catenin function and localization, we sought to identify novel β-catenin interacting partners by affinity purification coupled with tandem mass spectrometry in vascular smooth muscle cells (VSMCs), where β-catenin is involved in both physiological and pathological control of cell proliferation. Here, we report novel components of the VSMC β-catenin interactome.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_04:46:28.696.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterDeclan Williams
SpeciesList scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationListdihydroxylated residue; phosphorylated residue; monohydroxylated residue; iodoacetamide derivatized residue; deamidated residue
InstrumentLTQ Orbitrap Elite
Dataset History
RevisionDatetimeStatusChangeLog Entry
02018-07-13 03:19:00ID requested
12018-10-25 09:09:56announced
22018-12-04 03:52:04announcedUpdated project metadata.
32024-10-22 04:46:29announced2024-10-22: Updated project metadata.
Publication List
Dataset with its publication pending
Keyword List
curator keyword: Biological, Biomedical
submitter keyword: vascular smooth muscle cell, rat,Aorta, interactome, beta-catenin, LC-MS/MS
Contact List
John C. McDermott
contact affiliationDepartment of Biology, York University, Toronto, Ontario, Canada
contact emailjmcderm@yorku.ca
lab head
Declan Williams
contact affiliationUniversity of Toronto
contact emailgwillym.williams@utoronto.ca
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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