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PXD010386

PXD010386 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleA Critical Role of cTAGE5/MEA6 in Brain Development through Regulation of Trafficking of Cellular Components in Neurons
DescriptionNormal neural development is essential for the formation of neuronal networks and brain function. cTAGE5/MEA6 plays a critical role in the secretion of proteins. However, its roles in the transport of non-secretory cellular components and in brain development remain unknown. Here, we show that cTAGE5/MEA6 is essential for brain development and function. Conditional knockout of cTAGE5/MEA6 in the brain leads to severe defects in neural development, including deficits in dendrite outgrowth and branching, synapse formation and/or maintenance, astrocyte activation, and abnormal behaviors. We reveal that loss of cTAGE5/MEA6 affects the interaction between the coat protein complex II (COPII) components, SAR1 and SEC23, leading to persistent activation of SAR1 and defects in COPII vesicle formation and transport from the ER to Golgi, as well as disturbed trafficking of membrane components in neurons. These defects affect not only the transport of materials required for the development of dendrites and spines, but also the signaling pathways required for neuronal development. Since mutations in cTAGE5/MEA6 have been found in patients with Fahr’s disease, our study potentially also provides insight into the pathogenesis of this disorder.
HostingRepositoryPRIDE
AnnounceDate2018-12-04
AnnouncementXMLSubmission_2018-12-04_03:53:01.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterFeng Zhang
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
InstrumentLTQ Orbitrap Elite
Dataset History
RevisionDatetimeStatusChangeLog Entry
02018-07-11 07:35:11ID requested
12018-09-18 06:39:24announced
22018-12-04 03:53:02announcedUpdated project metadata.
Publication List
Dataset with its publication pending
Keyword List
curator keyword: Biological, Biomedical
submitter keyword: cTAGE5/MEA6
Brain development
COPII
vesicle trafficking
Contact List
Zhiheng Xu
contact affiliationInstitute of Genetics and Developmental Biology, Chinese Acadamy of Sciences
contact emailzhxu@genetics.ac.cn
lab head
Feng Zhang
contact affiliationInstitute of Genetics and Developmental Biology, CAS
contact emailzhang007360@aliyun.com
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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