PXD010383

PXD010383 is an original dataset announced via ProteomeXchange.

Title	Changes in the oligodendrocyte cell progenitor cell proteome with ageing
Description	Following CNS demyelination, adult oligodendrocyte progenitor cells (OPCs) can differentiate into new myelin-forming oligodendrocytes in a regenerative process called remyelination. While remyelination is very efficient in young adults, its efficiency declines progressively with ageing. Here we performed proteomic analysis on OPCs isolated acutely from the brains of neonate, young and aged female rats. Approximately 60% of the proteins are expressed at different levels in OPCs from neonates compared to their adult counterparts. The amount of myelin-associated and cell adhesion proteins are increased with age, while cholesterol-biosynthesis, transcription factors and cell cycle proteins decreased. Our experiments provide the first ageing OPC rodent proteome, revealing the distinct features of neonatal and adult OPCs, and providing new insights into why remyelination efficiency declines with ageing and potential roles for aged OPCs in other neurodegenerative diseases.
HostingRepository	PRIDE
AnnounceDate	2022-02-25
AnnouncementXML	Submission_2022-02-25_05:56:41.042.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Raghothama Chaerkady
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2018-07-11 06:52:53	ID requested
⏵ 1	2022-02-25 05:56:41	announced

de la Fuente AG, Queiroz RML, Ghosh T, McMurran CE, Cubillos JF, Bergles DE, Fitzgerald DC, Jones CA, Lilley KS, Glover CP, Franklin RJM, Changes in the Oligodendrocyte Progenitor Cell Proteome with Ageing. Mol Cell Proteomics, 19(8):1281-1302(2020) [pubmed]

ProteomeXchange project tag: Biology/Disease-Driven Human Proteome Project (B/D-HPP), Human Proteome Project

curator keyword: Biological, Biomedical

submitter keyword: oligodendrocyte cell progenitor cell, proteome, LC-MS, Tandem mass tags

Sonja Hess
contact affiliation	Associate Director Medimmune LLC, Gaithersburg, MD, US
contact email	hessso@medimmune.com
lab head
Raghothama Chaerkady
contact affiliation	MedImmune
contact email	chaerkadyr@medimmune.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/02/PXD010383

PRIDE project URI

• PRIDE
  1. PXD010383
     1. Label: PRIDE project
     2. Name: Changes in the oligodendrocyte cell progenitor cell proteome with ageing