PXD010380

PXD010380 is an original dataset announced via ProteomeXchange.

Title	Platelet proteome is affected by cancer presence and therapy
Description	Platelets play an important role in primary hemostasis, inflammation , (tumor) angiogenesis and cancer metastasis. Platelets are produced by megakaryocytes in the bone marrow and contain numerous bioactive proteins (e.g. growth factors, chemokine’s and proteases). These proteins inside platelets are either synthesized by the parental megakaryocytes or absorbed from the (micro)circulation. Therefore, it was postulated that changes in platelet protein content might indicate the presence or recurrence of a malignant tumor. We followed up the notion that both cancer and cancer therapy affect the platelet proteome. The aim of the current study was 1) to identify a pan-cancer proteome signature that could be used to discriminate patients with cancer from healthy individuals, and 2) to investigate the effect of cancer therapy on the platelet proteome. In this study, we included patients with cancer and healthy controls. Using global protein profiling by mass spectrometry-based proteomics we determined that the platelet proteome is affected by both cancer presence and antitumor therapy.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:25:24.166.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Sander Piersma
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2018-07-11 06:39:10	ID requested
1	2021-09-08 07:27:23	announced
⏵ 2	2024-10-22 05:25:32	announced	2024-10-22: Updated project metadata.

10.3390/ijms22158236;

Walraven M, Sabrkhany S, Knol JC, Dekker H, de Reus I, Piersma SR, Pham TV, Griffioen AW, Broxterman HJ, Oude Egbrink M, Verheul HMW, Jimenez CR, Effects of Cancer Presence and Therapy on the Platelet Proteome. Int J Mol Sci, 22(15):(2021) [pubmed]

curator keyword: Biological, Biomedical

submitter keyword: Human, platelets, label-free, chemotherapy, biomarker

Connie Ramona Jimenez
contact affiliation	OncoProteomics Laboratory, Dept of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands
contact email	c.jimenez@vumc.nl
lab head
Sander Piersma
contact affiliation	OncoProteomics Laboratory, dept of Medical Oncology, VUmc Medical Center, Amsterdam, The Netherlands
contact email	s.piersma@vumc.nl
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/09/PXD010380

PRIDE project URI

• PRIDE
  1. PXD010380
     1. Label: PRIDE project
     2. Name: Platelet proteome is affected by cancer presence and therapy