PXD010370

PXD010370 is an original dataset announced via ProteomeXchange.

Title	Chd4 controls Ripk3 dependent necroptosis during muscle regeneration
Description	We performed a label-free LC-MS/MS study to analyse the role of Chd4 regulation in MuSC in suppressing genes enabling programmed cell death as part of the muscle regeneration program. Lox-cre recombination was used to create a deletion mutant of the CHD4 chromatin modifier (exons 12-21). A pseudo "infection" with GFP was used as control. Proteomics analysis here serves as a method to compare the differentially deregulated proteins upon knockdown of Chd4 in MuSCs using Adenoviral CRE recombination.
HostingRepository	PRIDE
AnnounceDate	2020-04-02
AnnouncementXML	Submission_2020-06-12_04:39:05.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Carsten Kuenne
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2018-07-11 01:51:52	ID requested
1	2020-04-02 06:30:01	announced
⏵ 2	2020-06-12 04:39:06	announced	2020-06-12: Updated publication reference for PubMed record(s): 32433961.

Sreenivasan K, Ianni A, K, ü, nne C, Strilic B, G, ü, nther S, Perdiguero E, Kr, ü, ger M, Spuler S, Offermanns S, G, ó, mez-Del Arco P, Redondo JM, Munoz-Canoves P, Kim J, Braun T, Attenuated Epigenetic Suppression of Muscle Stem Cell Necroptosis Is Required for Efficient Regeneration of Dystrophic Muscles. Cell Rep, 31(7):107652(2020) [pubmed]

curator keyword: Biomedical

submitter keyword: Mus musculus, Muscle stem cells (MuSCs), Adenoviral, Chd4/NuRD regulation, Necroptosis, Label free LC-MS/MS

Marcus Krüger
contact affiliation	Marcus Krüger Lab, CECAD, University of Cologne, Germany
contact email	Marcus.Krueger@uni-koeln.de
lab head
Carsten Kuenne
contact affiliation	Max Planck Institute for Heart and Lung Research
contact email	carsten.kuenne@mpi-bn.mpg.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/04/PXD010370

PRIDE project URI

• PRIDE
  1. PXD010370
     1. Label: PRIDE project
     2. Name: Chd4 controls Ripk3 dependent necroptosis during muscle regeneration