PXD010362

PXD010362 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Proteomic analysis of extracellular vesicles (EVs) from 4T1 breast cancer cells upon paclitaxel treatment
Description	Increasing pre-clinical data suggest that chemotherapy may elicit pro-metastatic responses in breast cancer models. Primary tumours release extracellular vesicles (EVs) that can facilitate the seeding and growth of metastatic cancer cells in distant organs, but the effects of chemotherapy on pro-metastatic EVs are poorly understood. The goal of the project was to analyse the protein content in EVs released by the mouse breast cancer cell line 4T1 after treatment with the chemotherapeutic agent paclitaxel (PTX) or its vehicle control cremophor (CREMO).
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:49:59.698.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD010362
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Chiara Cianciaruso
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	Ammonia-loss; Phospho; Dehydrated; Oxidation; Acetyl; Carbamidomethyl
Instrument	LTQ Orbitrap Elite

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2018-07-10 06:07:07	ID requested
1	2019-01-02 01:12:11	announced
2	2019-01-07 03:28:10	announced	Updated publication reference for PubMed record(s): 30598531.
⏵ 3	2023-11-14 08:50:00	announced	2023-11-14: Updated project metadata.

Publication List

Keklikoglou I, Cianciaruso C, G, ü, ç E, Squadrito ML, Spring LM, Tazzyman S, Lambein L, Poissonnier A, Ferraro GB, Baer C, Cassar, á A, Guichard A, Iruela-Arispe ML, Lewis CE, Coussens LM, Bardia A, Jain RK, Pollard JW, De Palma M, Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models. Nat Cell Biol, 21(2):190-202(2019) [pubmed]
10.6019/PXD010362;

Keklikoglou I, Cianciaruso C, G, ü, ç E, Squadrito ML, Spring LM, Tazzyman S, Lambein L, Poissonnier A, Ferraro GB, Baer C, Cassar, á A, Guichard A, Iruela-Arispe ML, Lewis CE, Coussens LM, Bardia A, Jain RK, Pollard JW, De Palma M, Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models. Nat Cell Biol, 21(2):190-202(2019) [pubmed]

10.6019/PXD010362;

Keyword List

curator keyword: Biomedical
submitter keyword: 4T1, extracellular vesicles, paclitaxel

curator keyword: Biomedical

submitter keyword: 4T1, extracellular vesicles, paclitaxel

Contact List

Michele De Palma
contact affiliation	Angiogenesis and Tumor Microenvironment Lab The Swiss Institute for Experimental Cancer Research (ISREC) School of Life Sciences Ecole Polytechnique Fédérale de Lausanne (EPFL) Swiss Federal Institute of Technology, Lausanne, Switzerland
contact email	micheledepalma@epfl.ch
lab head
Chiara Cianciaruso
contact affiliation	EPFL
contact email	chiara.cianciaruso@epfl.ch
dataset submitter

Full Dataset Link List

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PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/01/PXD010362

PRIDE project URI

Repository Record List

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