PXD010260

PXD010260 is an original dataset announced via ProteomeXchange.

Title	Muscular invasiveness in bladder cancer
Description	Patients with bladder cancer need frequent controls over long follow-up time due to high recurrence rate and risk of conversion to muscle invasive cancer with poor prognosis. We identified cancer-related molecular signatures in apparently healthy bladder in patients with subsequent muscular invasiveness during follow-up. Global proteomics of the normal tissue biopsies revealed specific proteome fingerprints in these patients prior to subsequent muscular invasiveness. In these presumed normal samples, we detected modulations of proteins previously associated with different cancer types. This study indicates that analyzing apparently healthy tissue of a cancer-invaded organ may predict disease progression.
HostingRepository	PRIDE
AnnounceDate	2018-10-26
AnnouncementXML	Submission_2018-11-22_02:38:55.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Eystein Oveland
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2018-06-28 03:32:34	ID requested
1	2018-10-26 05:31:41	announced
⏵ 2	2018-11-22 02:38:56	announced	Updated publication reference for PubMed record(s): 30419021.

Berle M, Ghila L, Vethe H, Chaudhry A, Garberg H, Beisland C, Haaland Ø A, Oveland E, Halvorsen OJ, Davidsson T, Chera S, Novel protein signatures suggest progression to muscular invasiveness in bladder cancer. PLoS One, 13(11):e0206475(2018) [pubmed]

submitter keyword: Human, bladder cancer, label-free proteomics, Q-Exactive-HF

Magnus Berle
contact affiliation	University of Bergen, Department of Clinical Medicine
contact email	magnus.berle@gmail.com
lab head
Eystein Oveland
contact affiliation	Institute of Marine Research
contact email	eysteino@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/10/PXD010260

PRIDE project URI

• PRIDE
  1. PXD010260
     1. Label: PRIDE project
     2. Name: Muscular invasiveness in bladder cancer