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PXD010242

PXD010242 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteomics and phosphoproteomics of the diurnal cycle in chow and high fat high sucrose feed rats
DescriptionThere is growing evidence that energy metabolism and insulin action are regulated by mechanisms that follow a diurnal rhythm and it has been proposed that defects in Akt signalling are associated with the pathophysiology of metabolic disease. It is therefore important to investigate these parameters under physiology of the free-living state. We therefore examined the insulin action in muscle of chow or high fat, high sucrose diet-fed (HFHS) rats during the normal diurnal cycle. HFHS animals displayed hyperinsulinemia, however had reduced systemic glucose disposal and impaired muscle glucose uptake during the feeding period. Proteomics and phosphoproteomics was performed over the diurnal cycle in chow and HFHS rats.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_04:46:00.644.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterBenjamin Parker
SpeciesList scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationListphosphorylated residue; monohydroxylated residue; iodoacetamide derivatized residue
InstrumentOrbitrap Fusion; Q Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02018-06-27 03:17:30ID requested
12019-05-20 00:46:04announced
22024-10-22 04:46:01announced2024-10-22: Updated project metadata.
Publication List
Small L, Brandon AE, Parker BL, Deshpande V, Samsudeen AF, Kowalski GM, Reznick J, Wilks DL, Preston E, Bruce CR, James DE, Turner N, Cooney GJ, Reduced insulin action in muscle of high fat diet rats over the diurnal cycle is not associated with defective insulin signaling. Mol Metab, 25():107-118(2019) [pubmed]
10.1016/j.molmet.2019.04.006;
Keyword List
curator keyword: Biological, Biomedical
submitter keyword: insulin signaling, high fat high sucrose diet, phosphoproteomics
Contact List
Benjamin Parker
contact affiliationThe University of Sydney
contact emailbenjamin.parker@sydney.edu.au
lab head
Benjamin Parker
contact affiliationThe University of Melbourne
contact emailben.parker@unimelb.edu.au
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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