PXD010242 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteomics and phosphoproteomics of the diurnal cycle in chow and high fat high sucrose feed rats |
Description | There is growing evidence that energy metabolism and insulin action are regulated by mechanisms that follow a diurnal rhythm and it has been proposed that defects in Akt signalling are associated with the pathophysiology of metabolic disease. It is therefore important to investigate these parameters under physiology of the free-living state. We therefore examined the insulin action in muscle of chow or high fat, high sucrose diet-fed (HFHS) rats during the normal diurnal cycle. HFHS animals displayed hyperinsulinemia, however had reduced systemic glucose disposal and impaired muscle glucose uptake during the feeding period. Proteomics and phosphoproteomics was performed over the diurnal cycle in chow and HFHS rats. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_04:46:00.644.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Benjamin Parker |
SpeciesList | scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116; |
ModificationList | phosphorylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Orbitrap Fusion; Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2018-06-27 03:17:30 | ID requested | |
1 | 2019-05-20 00:46:04 | announced | |
⏵ 2 | 2024-10-22 04:46:01 | announced | 2024-10-22: Updated project metadata. |
Publication List
Small L, Brandon AE, Parker BL, Deshpande V, Samsudeen AF, Kowalski GM, Reznick J, Wilks DL, Preston E, Bruce CR, James DE, Turner N, Cooney GJ, Reduced insulin action in muscle of high fat diet rats over the diurnal cycle is not associated with defective insulin signaling. Mol Metab, 25():107-118(2019) [pubmed] |
10.1016/j.molmet.2019.04.006; |
Keyword List
curator keyword: Biological, Biomedical |
submitter keyword: insulin signaling, high fat high sucrose diet, phosphoproteomics |
Contact List
Benjamin Parker |
contact affiliation | The University of Sydney |
contact email | benjamin.parker@sydney.edu.au |
lab head | |
Benjamin Parker |
contact affiliation | The University of Melbourne |
contact email | ben.parker@unimelb.edu.au |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/05/PXD010242 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD010242
- Label: PRIDE project
- Name: Proteomics and phosphoproteomics of the diurnal cycle in chow and high fat high sucrose feed rats