PXD010232

PXD010232 is an original dataset announced via ProteomeXchange.

Title	Hypolipidemic effects of Tamarindus indica fruit pulp extract
Description	In this study, the hypolipidemic effects of Tamarindus indica fruit pulp extract (Tifpe) in the serum obtained from diet-induced hypercholesterolemic hamsters were investigated using two-dimensional gel electrophoresis and mass spectrometry. Significantly altered levels of serum proteins were validated using ELISA. Hamsters fed with Tifpe, both in the absence and presence of high-cholesterol diet, were shown to have significantly reduced levels of serum triglyceride, LDL-C and total cholesterol. The Tifpe fed non-hypercholesterolemic hamsters also showed significant enhanced levels of serum apolipoprotein A1 (APOA1), antithrombin III (ATIII), transferrin (TF), transthyretin and vitamin D binding protein (VDBP). In diet-induced hypercholesterolemic hamsters, APOA1, ATIII and TF, which were relatively low in levels, became significantly enhanced when the hamsters were fed with Tifpe. These Tifpe-fed hypercholesterolemic hamsters also showed significant higher levels of serum VDBP. Ingenuity Pathway Analysis of the Tifpe modulated serum proteins singled out “Lipid metabolism, molecular transport, small molecule biochemistry” as the top network. Our results suggest that the hypolipidemic effects of Tifpe are associated with alterations of serum proteins that are known to be cardioprotective and involved in the metabolism of lipids.
HostingRepository	PRIDE
AnnounceDate	2018-10-04
AnnouncementXML	Submission_2018-10-04_08:58:51.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jaime Jayapalan
SpeciesList	scientific name: Mesocricetus auratus (Golden hamster); NCBI TaxID: 10036;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	4800 Proteomics Analyzer

Revision	Datetime	Status	ChangeLog Entry
0	2018-06-26 08:58:00	ID requested
⏵ 1	2018-10-04 08:58:53	announced

Lim CY, Junit SM, Aziz AA, Jayapalan JJ, Hashim OH, The hypolipidemic effects of Tamarindus indica fruit pulp extract in normal and diet-induced hypercholesterolemic hamsters are associated with altered levels of serum proteins. Electrophoresis, 39(23):2965-2973(2018) [pubmed]

curator keyword: Biological

submitter keyword: Tamarindus indica, fruit pulp extract, hamsters, hypolipidemia, serum proteins

Onn Haji Hashim
contact affiliation	Department of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia
contact email	onnhashim@um.edu.my
lab head
Jaime Jayapalan
contact affiliation	University of Malaya
contact email	jaime_jacklyn@um.edu.my
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD010232
     1. Label: PRIDE project
     2. Name: Hypolipidemic effects of Tamarindus indica fruit pulp extract