PXD010222

PXD010222 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Chemical crosslinking mass spectrometry reveals the conformational landscape of the activation helix of PPARγ; a model for ligand-dependent antagonism
Description	the project presents solution analysis of PPARγ H12 conformational mobility driven by pharmaceutically distinct compounds and sequence specific regulatory peptides by label-free quantitative cross-linking mass spectrometry. This study reveals a model of ligand-dependent antagonism of PPARγ by precisely characterizing H12 mobility as a function of ligand and peptide bound.
HostingRepository	PRIDE
AnnounceDate	2018-08-29
AnnouncementXML	Submission_2018-08-29_06:08:40.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jie Zheng
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2018-06-26 02:09:39	ID requested
⏵ 1	2018-08-29 06:08:51	announced

Publication List

Zheng J, Corzo C, Chang MR, Shang J, Lam VQ, Brust R, Blayo AL, Bruning JB, Kamenecka TM, Kojetin DJ, Griffin PR,
a Model for Ligand-Dependent Antagonism. Structure, 26(11):1431-1439.e6(2018) [pubmed]

Zheng J, Corzo C, Chang MR, Shang J, Lam VQ, Brust R, Blayo AL, Bruning JB, Kamenecka TM, Kojetin DJ, Griffin PR,

a Model for Ligand-Dependent Antagonism. Structure, 26(11):1431-1439.e6(2018) [pubmed]

Keyword List

curator keyword: Biological
submitter keyword: XL-MS

curator keyword: Biological

submitter keyword: XL-MS

Contact List

Pat Griffin
contact affiliation	The scripps research institute, jupiter, Florida
contact email	pgriffin@scripps.edu
lab head
Jie Zheng
contact affiliation	Scripps FL
contact email	27jie.zheng@gmail.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/08/PXD010222
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/08/PXD010222

PRIDE project URI

Repository Record List

[ + ]