PXD010215

PXD010215 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Proteomic Pathway Analysis Reveals Inflammation Increases Myeloid-Derived Suppressor Cell Resistance to Apoptosis
Description	Myeloid derived suppressor cells (MDSC) accumulate in patients and animals with cancer where they mediate systemic immune suppression and obstruct immune based cancer therapies. To determine how inflammation enhances MDSC levels and activity we used mass spectrometry to identify proteins produced by MDSC induced in highly inflammatory settings. This experiment includes six "shotgun" RAW files for peptides produced through trypsin digestion. Accurate precursor masses were measured in the FT and unit resolution fragment ions were measured in the linear ion trap. Experimental hierarchy: inflammatory4T1IL1b/tech1 balbc_4T1_IL1b_1.mzML inflammatory4T1IL1b/tech2 balbc_4T1_IL1b_2.mzML conventional4T1/tech1 Olesya-4T1_balbc_1.mzML conventional-4T1/tech2 Olesya-4T1_balbc_2.mzML TLR4knockout-4T1/tech1 TLR4_4T1_1.mzML TLR4knockout-4T1/tech2 TLR4_4T1_2.mzML
HostingRepository	MassIVE
AnnounceDate	2018-06-25
AnnouncementXML	Submission_2018-06-25_05:39:30.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	David L. Tabb
SpeciesList	scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090;
ModificationList	Carbamidomethyl; Oxidation
Instrument	LTQ FT

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2018-06-25 05:01:39	ID requested
⏵ 1	2018-06-25 05:39:32	announced

Publication List

Chornoguz O, Grmai L, Sinha P, Artemenko KA, Zubarev RA, Ostrand-Rosenberg S, Proteomic pathway analysis reveals inflammation increases myeloid-derived suppressor cell resistance to apoptosis. Mol Cell Proteomics, 10(3):M110.002980(2011) [pubmed]

Chornoguz O, Grmai L, Sinha P, Artemenko KA, Zubarev RA, Ostrand-Rosenberg S, Proteomic pathway analysis reveals inflammation increases myeloid-derived suppressor cell resistance to apoptosis. Mol Cell Proteomics, 10(3):M110.002980(2011) [pubmed]

Keyword List

submitter keyword: MDSC, Inflammation, Apoptosis

submitter keyword: MDSC, Inflammation, Apoptosis

Contact List

Suzanne Ostrand-Rosenberg
contact affiliation	University of Maryland Baltimore County (UMBC)
contact email	srosenbe@umbc.edu
lab head
David L. Tabb
contact affiliation	Vanderbilt University Medical Center
contact email	david.l.tabb@vanderbilt.edu
dataset submitter

Full Dataset Link List

MassIVE dataset URI
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MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000082500