PXD010215
PXD010215 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteomic Pathway Analysis Reveals Inflammation Increases Myeloid-Derived Suppressor Cell Resistance to Apoptosis |
Description | Myeloid derived suppressor cells (MDSC) accumulate in patients and animals with cancer where they mediate systemic immune suppression and obstruct immune based cancer therapies. To determine how inflammation enhances MDSC levels and activity we used mass spectrometry to identify proteins produced by MDSC induced in highly inflammatory settings. This experiment includes six "shotgun" RAW files for peptides produced through trypsin digestion. Accurate precursor masses were measured in the FT and unit resolution fragment ions were measured in the linear ion trap. Experimental hierarchy: inflammatory4T1IL1b/tech1 balbc_4T1_IL1b_1.mzML inflammatory4T1IL1b/tech2 balbc_4T1_IL1b_2.mzML conventional4T1/tech1 Olesya-4T1_balbc_1.mzML conventional-4T1/tech2 Olesya-4T1_balbc_2.mzML TLR4knockout-4T1/tech1 TLR4_4T1_1.mzML TLR4knockout-4T1/tech2 TLR4_4T1_2.mzML |
HostingRepository | MassIVE |
AnnounceDate | 2018-06-25 |
AnnouncementXML | Submission_2018-06-25_05:39:30.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | David L. Tabb |
SpeciesList | scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090; |
ModificationList | Carbamidomethyl; Oxidation |
Instrument | LTQ FT |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2018-06-25 05:01:39 | ID requested | |
⏵ 1 | 2018-06-25 05:39:32 | announced |
Publication List
Chornoguz O, Grmai L, Sinha P, Artemenko KA, Zubarev RA, Ostrand-Rosenberg S, Proteomic pathway analysis reveals inflammation increases myeloid-derived suppressor cell resistance to apoptosis. Mol Cell Proteomics, 10(3):M110.002980(2011) [pubmed] |
Keyword List
submitter keyword: MDSC, Inflammation, Apoptosis |
Contact List
Suzanne Ostrand-Rosenberg | |
---|---|
contact affiliation | University of Maryland Baltimore County (UMBC) |
contact email | srosenbe@umbc.edu |
lab head | |
David L. Tabb | |
contact affiliation | Vanderbilt University Medical Center |
contact email | david.l.tabb@vanderbilt.edu |
dataset submitter |
Full Dataset Link List
MassIVE dataset URI |
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000082500 |