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PXD010215

PXD010215 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteomic Pathway Analysis Reveals Inflammation Increases Myeloid-Derived Suppressor Cell Resistance to Apoptosis
DescriptionMyeloid derived suppressor cells (MDSC) accumulate in patients and animals with cancer where they mediate systemic immune suppression and obstruct immune based cancer therapies. To determine how inflammation enhances MDSC levels and activity we used mass spectrometry to identify proteins produced by MDSC induced in highly inflammatory settings. This experiment includes six "shotgun" RAW files for peptides produced through trypsin digestion. Accurate precursor masses were measured in the FT and unit resolution fragment ions were measured in the linear ion trap. Experimental hierarchy: inflammatory4T1IL1b/tech1 balbc_4T1_IL1b_1.mzML inflammatory4T1IL1b/tech2 balbc_4T1_IL1b_2.mzML conventional4T1/tech1 Olesya-4T1_balbc_1.mzML conventional-4T1/tech2 Olesya-4T1_balbc_2.mzML TLR4knockout-4T1/tech1 TLR4_4T1_1.mzML TLR4knockout-4T1/tech2 TLR4_4T1_2.mzML
HostingRepositoryMassIVE
AnnounceDate2018-06-25
AnnouncementXMLSubmission_2018-06-25_05:39:30.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterDavid L. Tabb
SpeciesList scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090;
ModificationListCarbamidomethyl; Oxidation
InstrumentLTQ FT
Dataset History
RevisionDatetimeStatusChangeLog Entry
02018-06-25 05:01:39ID requested
12018-06-25 05:39:32announced
Publication List
Chornoguz O, Grmai L, Sinha P, Artemenko KA, Zubarev RA, Ostrand-Rosenberg S, Proteomic pathway analysis reveals inflammation increases myeloid-derived suppressor cell resistance to apoptosis. Mol Cell Proteomics, 10(3):M110.002980(2011) [pubmed]
Keyword List
submitter keyword: MDSC, Inflammation, Apoptosis
Contact List
Suzanne Ostrand-Rosenberg
contact affiliationUniversity of Maryland Baltimore County (UMBC)
contact emailsrosenbe@umbc.edu
lab head
David L. Tabb
contact affiliationVanderbilt University Medical Center
contact emaildavid.l.tabb@vanderbilt.edu
dataset submitter
Full Dataset Link List
MassIVE dataset URI
Dataset FTP location
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