PXD010211

PXD010211 is an original dataset announced via ProteomeXchange.

Title	Biofilm formation displays intrinsic offensive and defensive features of Bacillus cereus
Description	Biofilm formation is a strategy of many bacterial species to adapt to a variety of stresses and has become a part of infections, contaminations or beneficial interactions. In this study, we demonstrate that profound physiological changes permit Bacillus cereus to switch from a floating to a sessile lifestyle, to undergo further maturation of the biofilm, and to differentiate into offensive or defensive populations. The rearrangement of nucleotides, sugars, amino acids and energy metabolism lead to changes promoting reinforcement of the cell wall, rigidity of the membrane, activation of ROS detoxification or secondary metabolite production, all contributing to defend biofilm cells from external aggressions. However, floating cells maintain a fermentative metabolic status that ensures a higher aggressiveness against hosts, evidenced by the production of toxins and other virulent factors. Our findings argue in favor of the metabolic versatility of B. cereus and the fine tuning of these gene expression which grant this species to move to any of these two distinct subpopulations, necessary to face changeable environmental conditions.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:04:47.719.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Sergio Ciordia
SpeciesList	scientific name: Bacillus cereus (strain ATCC 14579 / DSM 31); NCBI TaxID: 226900;
ModificationList	No PTMs are included in the dataset
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2018-06-25 02:25:13	ID requested
1	2020-05-26 11:53:32	announced
⏵ 2	2024-10-22 05:04:53	announced	2024-10-22: Updated project metadata.

10.1038/s41522-019-0112-7;

Caro-Astorga J, Frenzel E, Perkins JR, Á, lvarez-Mena A, de Vicente A, Ranea JAG, Kuipers OP, Romero D, . NPJ Biofilms Microbiomes, 6():3(2020) [pubmed]

curator keyword: Biological, Biomedical

submitter keyword: attack defence, planktonics,Bacillus, cereus, toxins, biofilm, antimicrobials

Diego Romero
contact affiliation	Instituto de Hortofruticultura Subtropical y Mediterránea ‘‘La Mayora’’ –Departamento de Microbiología, Universidad de Málaga, Bulevar Louis Pasteur 31 (Campus Universitario de Teatinos), 29071 Málaga, Spain
contact email	diego_romero@uma.es
lab head
Sergio Ciordia
contact affiliation	Spanish National Center for Biotechnology
contact email	sciordia@cnb.csic.es
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/05/PXD010211

PRIDE project URI

• PRIDE
  1. PXD010211
     1. Label: PRIDE project
     2. Name: Biofilm formation displays intrinsic offensive and defensive features of Bacillus cereus