PXD010183

PXD010183 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Cytosolic fraction of MCF7 cells, SLC22A18 KD
Description	The SLC22A18 gene, which encodes an orphan transporter, is located at the 11p15.5 imprinted region, an important tumor-suppressor gene region. However, the role of SLC22A18 in tumor suppression remains unclear. Here, we investigated the involvement of SLC22A18 in cell growth, invasion and drug resistance of MCF7 human breast cancer cell line. Western blot analysis indicated that SLC22A18 is predominantly expressed at intracellular organelle membranes. Quantitative proteomics showed that knockdown of SLC22A18 significantly altered the expression of 578 (31.0%) out of 1867 proteins identified, including proteins related to malignancy and poor prognosis of breast cancer.
HostingRepository	jPOST
AnnounceDate	2019-06-01
AnnouncementXML	Submission_2022-09-18_03:09:57.512.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Sumio Ohtsuki
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	S-carboxamidomethyl-L-cysteine; L-methionine sulfoxide; O-phospho-L-serine; O-phospho-L-threonine
Instrument	TripleTOF 5600

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2018-06-22 01:23:28	ID requested
1	2019-05-31 08:00:06	announced
2	2021-02-04 17:18:01	announced	2021-02-04: Updated FTP location.
⏵ 3	2022-09-18 03:09:58	announced	2022-09-18: Updated FTP location.

Publication List

Ito S, Fujino Y, Ogata S, Hirayama-Kurogi M, Ohtsuki S, Involvement of an Orphan Transporter, SLC22A18, in Cell Growth and Drug Resistance of Human Breast Cancer MCF7 Cells. J Pharm Sci, 107(12):3163-3170(2018) [pubmed]

Ito S, Fujino Y, Ogata S, Hirayama-Kurogi M, Ohtsuki S, Involvement of an Orphan Transporter, SLC22A18, in Cell Growth and Drug Resistance of Human Breast Cancer MCF7 Cells. J Pharm Sci, 107(12):3163-3170(2018) [pubmed]

Keyword List

submitter keyword: MCF7, SLC22A18, Cytosol, SWATH-MS

submitter keyword: MCF7, SLC22A18, Cytosol, SWATH-MS

Contact List

Sumio Ohtsuki
lab head
Sumio Ohtsuki
contact affiliation	Kumamoto University
dataset submitter

Full Dataset Link List

jPOST dataset URI
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST000446/

jPOST dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST000446/