PXD010181

PXD010181 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Multiomics reveal non-alcoholic fatty livere disease in rats following chronic exposure to an ultra-low dose of Roundup herbicide
Description	The impairment of liver function by low environmentally relevant doses of glyphosate-based herbicides (GBH) is still a debatable and unresolved matter. Previously we have shown that rats administeres for 2 years with 0.1ppb of a Roundup GBH formulation showed signs of enhance liver injury as indicated by anatomorphological, blood/urine biochemical changes and transcriptome profiling. Here we present a multiomic study combining metabolome and proteome liver analyses to obtain further insight into the Roundup-induced pathology. Proteins significantly disutrbed (214 out of 1906 detected, q < 0.05) were involved in organonitrogen metabolism and fatty acid B-oxidation. Proteome disturbances reflected peroxisomal proliferation, steatosis and necrosis.
HostingRepository	PRIDE
AnnounceDate	2018-08-22
AnnouncementXML	Submission_2018-08-22_02:06:45.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	George Renney
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap Velos

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2018-06-21 06:49:10	ID requested
⏵ 1	2018-08-22 02:06:46	announced

Publication List

Dataset with its publication pending

Dataset with its publication pending

Keyword List

curator keyword: Biological
submitter keyword: Roundup, Liver, Proteomics

curator keyword: Biological

submitter keyword: Roundup, Liver, Proteomics

Contact List

Proteomics Facility Kings
contact affiliation	Kings College University London
contact email	malcolm.ward@kcl.ac.uk
lab head
George Renney
contact affiliation	Kings
contact email	george_renney@hotmail.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/08/PXD010181
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/08/PXD010181

PRIDE project URI

Repository Record List

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