PXD010138

PXD010138 is an original dataset announced via ProteomeXchange.

Title	Human brain Alzheimer's
Description	Alzheimer’s disease (AD) is the most common neurodegenerative disorder being characterized by progressive impairment of memory and cognition, resulting in dementia. To investigate brain region vulnerability to AD and which pathways are altered in certain areas in AD, we performed proteomic profiling of human brain samples during AD progression in regions early (medial temporal lobe - MTL) and late affected (neocortex) by tau pathology. We employed a mass spectrometry-based approach to interrogate the human brain proteome during AD progression (B/B stages) in four distinct brain regions: entorhinal cortex (EC), parahippocampal cortex (PHC), temporal cortex (TC) and frontal cortex (FC). Importantly, we wanted to evaluate brain areas that are affected by tau pathology in different disease stages, in order to gain insights if there are common mechanisms or patterns shared between different brain regions during disease progression. A total of 103 samples were analyzed by nanoLC-MS/MS.
HostingRepository	PRIDE
AnnounceDate	2019-07-01
AnnouncementXML	Submission_2019-07-01_08:04:02.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Melinda Rezeli
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2018-06-15 02:16:16	ID requested
⏵ 1	2019-07-01 08:04:03	announced

Mendon, ç, a CF, Kuras M, Nogueira FCS, Pl, á I, Hortob, á, gyi T, Csiba L, Palkovits M, Renner É, D, ö, me P, Marko-Varga G, Domont GB, Rezeli M, Proteomic signatures of brain regions affected by tau pathology in early and late stages of Alzheimer's disease. Neurobiol Dis, 130():104509(2019) [pubmed]

ProteomeXchange project tag: Human Brain Proteome Project (HUPO_HBPP) (B/D-HPP)

submitter keyword: Alzheimer's disease, human brain, QE

Gyögy Marko-Varga
contact affiliation	Lund University, Dept. Biomedical Engineering
contact email	gyorgy.marko-varga@bme.lth.se
lab head
Melinda Rezeli
contact affiliation	Lund University
contact email	melinda.rezeli@bme.lth.se
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/07/PXD010138

PRIDE project URI

• PRIDE
  1. PXD010138
     1. Label: PRIDE project
     2. Name: Human brain Alzheimer's