PXD010114 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Mouse femur LC-MSMS upon weightlessness |
Description | Bone loss and immune dysregulation are among the main adverse outcomes of spaceflight challenging astronaut’s health and safety. However, consequences on B cell development and responses are still under-investigated. Up to now, most studies addressing these questions were performed using an amphibian species. Consequently, we used advanced proteomics analysis of femur bone and marrow of mice flown for one month on board the BION-M1 biosatellite, to determine whether extreme conditions encountered during a real spaceflight affect B cell development in mice and to examine reversibility of the effects upon return to Earth. Our data revealed that adverse effects on B lymphopoiesis were more marked one week after landing and that this phenomenon was associated with a 41% reduction of B cells in the spleen. Thus, the effects of spaceflight persisted during at least one week after landing. These reductions may contribute to explain increased susceptibility to infection even if we confirmed that animals were able to mount a humoral immune response. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_04:45:54.280.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Fabrice BERTILE |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive Plus |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2018-06-13 07:43:41 | ID requested | |
1 | 2018-12-11 07:13:45 | announced | |
⏵ 2 | 2024-10-22 04:46:02 | announced | 2024-10-22: Updated project metadata. |
Publication List
10.1096/fj.201801463r; |
Tascher G, Gerbaix M, Maes P, Chazarin B, Ghislin S, Antropova E, Vassilieva G, Ouzren-Zarhloul N, Gauquelin-Koch G, Vico L, Frippiat JP, Bertile F, Analysis of femurs from mice embarked on board BION-M1 biosatellite reveals a decrease in immune cell development, including B cells, after 1 wk of recovery on Earth. FASEB J, 33(3):3772-3783(2019) [pubmed] |
Keyword List
curator keyword: Biological |
submitter keyword: LC-MSMS, Immunity,Mouse, Bone, Bone marrow, spaceflight, lymphopoeisis |
Contact List
Sarah Cianférani |
contact affiliation | Laboratoire de Spectrométrie de Masse BioOrganique, Analytical Science department, IPHC, CNRS, Strasbourg University, UMR7178, Stasbourg, France |
contact email | sarah.cianferani@unistra.fr |
lab head | |
Fabrice BERTILE |
contact affiliation | CNRS |
contact email | fbertile@unistra.fr |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD010114
- Label: PRIDE project
- Name: Mouse femur LC-MSMS upon weightlessness