PXD010114

PXD010114 is an original dataset announced via ProteomeXchange.

Title	Mouse femur LC-MSMS upon weightlessness
Description	Bone loss and immune dysregulation are among the main adverse outcomes of spaceflight challenging astronaut’s health and safety. However, consequences on B cell development and responses are still under-investigated. Up to now, most studies addressing these questions were performed using an amphibian species. Consequently, we used advanced proteomics analysis of femur bone and marrow of mice flown for one month on board the BION-M1 biosatellite, to determine whether extreme conditions encountered during a real spaceflight affect B cell development in mice and to examine reversibility of the effects upon return to Earth. Our data revealed that adverse effects on B lymphopoiesis were more marked one week after landing and that this phenomenon was associated with a 41% reduction of B cells in the spleen. Thus, the effects of spaceflight persisted during at least one week after landing. These reductions may contribute to explain increased susceptibility to infection even if we confirmed that animals were able to mount a humoral immune response.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:45:54.280.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Fabrice BERTILE
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2018-06-13 07:43:41	ID requested
1	2018-12-11 07:13:45	announced
⏵ 2	2024-10-22 04:46:02	announced	2024-10-22: Updated project metadata.

10.1096/fj.201801463r;

Tascher G, Gerbaix M, Maes P, Chazarin B, Ghislin S, Antropova E, Vassilieva G, Ouzren-Zarhloul N, Gauquelin-Koch G, Vico L, Frippiat JP, Bertile F, Analysis of femurs from mice embarked on board BION-M1 biosatellite reveals a decrease in immune cell development, including B cells, after 1 wk of recovery on Earth. FASEB J, 33(3):3772-3783(2019) [pubmed]

curator keyword: Biological

submitter keyword: LC-MSMS, Immunity,Mouse, Bone, Bone marrow, spaceflight, lymphopoeisis

Sarah Cianférani
contact affiliation	Laboratoire de Spectrométrie de Masse BioOrganique, Analytical Science department, IPHC, CNRS, Strasbourg University, UMR7178, Stasbourg, France
contact email	sarah.cianferani@unistra.fr
lab head
Fabrice BERTILE
contact affiliation	CNRS
contact email	fbertile@unistra.fr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/12/PXD010114

PRIDE project URI

• PRIDE
  1. PXD010114
     1. Label: PRIDE project
     2. Name: Mouse femur LC-MSMS upon weightlessness