PXD010097 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | EIF3F regulates cell migration and metastasis in human lung adenocarcinoma |
Description | The basic understanding of the biological effects of eukaryotic translation initiation factors (EIFs) remains incomplete. Here, we analyzed the function of EIF3F, which is commonly found to be overexpressed in human lung adenocarcinoma, and discovered that EIF3F promotes cell migration and metastasis in vivo. The underpinning molecular mechanisms involved the upregulation of a cluster of 34 metastasis-promoting genes including Snail2 (SLUG), as revealed by proteomics combined with immuno-affinity purification of EIF3F and ChIP-seq/Q-PCR analyses. The interaction between EIF3F and Signal Transducer and Activator of Transcription 3 (STAT3) controlled the EIF3F-mediated increase in Snail2 expression and cellular invasion, which were specifically abrogated using the STAT3 inhibitor nifuroxazide. Our findings demonstrate the role of EIF3F in the molecular control of cell migration, invasion and metastasis. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_04:45:36.205.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Dupuy Jean-William |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | deaminated residue; monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2018-06-12 02:05:41 | ID requested | |
1 | 2019-09-25 07:54:57 | announced | |
⏵ 2 | 2024-10-22 04:45:38 | announced | 2024-10-22: Updated project metadata. |
Publication List
Esteves P, Dard L, Brillac A, Hubert C, Sarlak S, Rousseau B, Dumon E, Izotte J, Bonneu M, Lacombe D, Dupuy JW, Amoedo N, Rossignol R, Nuclear control of lung cancer cells migration, invasion and bioenergetics by eukaryotic translation initiation factor 3F. Oncogene, 39(3):617-636(2020) [pubmed] |
10.1038/s41388-019-1009-x; |
Keyword List
curator keyword: Biological |
submitter keyword: cancer,Lung, human lung adenocarcinoma, label-free quantitative proteome analysis |
Contact List
Rodrigue Rossignol |
contact affiliation | INSERM U1211, University of Bordeaux, CHU Pellegrin, Ecole des Sages Femmes, Place Amélie Raba Léon, 33000 Bordeaux |
contact email | rodrigue.rossignol@u-bordeaux.fr |
lab head | |
Dupuy Jean-William |
contact affiliation | Plateforme Proteome Bordeaux |
contact email | jean-william.dupuy@u-bordeaux.fr |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD010097
- Label: PRIDE project
- Name: EIF3F regulates cell migration and metastasis in human lung adenocarcinoma