PXD010087

PXD010087 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	A SWATH LABEL-FREE PROTEOMICS INSIGHT INTO THE FAAH-/- MOUSE LIVER
Description	Fatty acid amide hydrolase (FAAH) is an important enzyme for lipid metabolism and an interesting pharmacological target, given its role in anandamide breakdown. The FAAH-/- genotype is the most widely used mouse model to achieve complete abolition of this enzyme. In this paper we explore, by means of label-free SWATH proteomics, the changes in protein expression occurring in the liver of FAAH-/- mice. We identified several altered biological processes and pathways, like fatty acid synthesis and glycolysis, which explain the observed phenotype of this mouse. We also observed the alteration of other proteins, like carboxylesterases and S-methyltransferases, apparently not immediately related to FAAH, but known to have important biological roles.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:45:46.009.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Andrea Armirotti
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	iodoacetamide derivatized residue
Instrument	TripleTOF 5600

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2018-06-11 03:00:20	ID requested
1	2018-08-20 03:13:09	announced
⏵ 2	2024-10-22 04:45:52	announced	2024-10-22: Updated project metadata.

Publication List

10.1038/s41598-018-30553-z;
Hamid Z, Summa M, Armirotti A, Mouse Liver. Sci Rep, 8(1):12142(2018) [pubmed]

10.1038/s41598-018-30553-z;

Hamid Z, Summa M, Armirotti A, Mouse Liver. Sci Rep, 8(1):12142(2018) [pubmed]

Keyword List

curator keyword: Biological
submitter keyword: FAAH, SWATH, Liver proteomics

curator keyword: Biological

submitter keyword: FAAH, SWATH, Liver proteomics

Contact List

Andrea Armirotti
contact affiliation	Analytical Chemistry Lab, Istituto Italiano di Tecnologia
contact email	andrea.armirotti@iit.it
lab head
Andrea Armirotti
contact affiliation	Analytical Chemistry Lab, Fondazione Istituto Italiano di Tecnologia
contact email	andrea.armirotti@iit.it
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/08/PXD010087
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/08/PXD010087

PRIDE project URI

Repository Record List

[ + ]