PXD010059

PXD010059 is an original dataset announced via ProteomeXchange.

Title	Reversible SAHH inhibitor protects against glomerulonephritis in lupus-prone NZB/NZW F1 mice by modulating α-actinin-4 associated skeleton organization of podocytes
Description	Glomerulonephritis is one of the major complications and causes of death in systemic lupus erythematosus (SLE). Podocytes can be injured in many forms of glomerular disease, characteristic changes are actin cytoskeleton reorganization of involved foot process. ACTN4, encodes α-actinin-4, an actin-binding and crosslinking protein localized to podocytes in renal glomerulus. Abnormal expression of α-actinin-4 in mice leads to proteinuria and podocyte damage. DZ2002, a reversible S-adenosyl-L-homocysteine hydrolase (SAHH) inhibitor with immunosuppressive properties and potent therapeutic activity against various autoimmune diseases in mice. Here, we found that DZ2002 could significantly ameliorate nephritis of lupus-prone mice. Our results showed that DZ2002 decreased the accumulation of α-actinin-4, inhibited expression of integrin-linked kinase and downstream phosphorylation of β1-integrin.
HostingRepository	PRIDE
AnnounceDate	2019-11-12
AnnouncementXML	Submission_2019-11-12_11:39:44.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xing Liu
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2018-06-07 05:49:31	ID requested
⏵ 1	2019-11-12 11:39:45	announced

He S, Liu X, Lin Z, Liu Y, Gu L, Zhou H, Tang W, Zuo J, -actinin-4 expression and stabilizing integrin-cytoskeleton linkage. Arthritis Res Ther, 21(1):40(2019) [pubmed]

curator keyword: Biological

submitter keyword: SAHH inhibitor, glomerulonephritis, α-actinin-4, integrin-linked kinase, skeleton organization, podocyte injury

Hu Zhou
contact affiliation	Department of Analytical Chemistry and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
contact email	zhouhu@simm.ac.cn
lab head
Xing Liu
contact affiliation	None
contact email	liuxinghappy@simm.ac.cn
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD010059
     1. Label: PRIDE project
     2. Name: Reversible SAHH inhibitor protects against glomerulonephritis in lupus-prone NZB/NZW F1 mice by modulating α-actinin-4 associated skeleton organization of podocytes