This study shed light on the protein profile of the venomous extract and the skin mucus from S. plumieri, potentially contributing with fundamental information for future basic research, and even – through a better understanding of venomous fish toxinology – aiding in the search for new clinical strategies to treat the envenomation. Finally, seeing as fish venoms remain considerably less studied when compared to terrestrial venoms, the exploration of their full potential opens a myriad of possibilities for the development of new drugs and for a deeper understanding of complex physiological processes.