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PXD009956

PXD009956 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleHaemonchus contortus Global Somatic Proteome
DescriptionParasitic nematodes cause diseases that adversely impact on animal health and production. Although advances in genomics and transcriptomics are revolutionising the way we explore these parasites, there is a dearth of proteomic data to underpin or support fundamental discoveries. Here, using a high throughput LC-MS/MS-based approach, we undertook the first large-scale (global) proteomic investigation of Haemonchus contortus (the barber's pole worm), one of the most important parasitic nematodes of livestock animals worldwide. In total, 2487 unique H. contortus proteins, representing five key developmental stages [i. e. eggs, third-stage (L3) and fourth-stage (L4) larvae; female (Af) and male adults (Am)] were identified and quantified with high confidence. Bioinformatic analyses of the somatic proteome of H. contortus discovered substantial alterations in protein profiles during the life cycle, particularly in the transition from the free-living to the parasitic phase, and identified groups of key proteins involved specifically in feeding, digestion, metabolism, development, parasite-host interactions (including immunomodulation), structural remodelling of the body wall and other adaptive processes during the parasitic phase. This global proteomic data set will likely facilitate future molecular, biochemical and physiological investigations of H. contortus and related nematodes, and should underpin the discovery of novel intervention targets against haemonchosis.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_04:06:18.560.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterTao Wang
SpeciesList scientific name: Haemonchus contortus (Barber pole worm); NCBI TaxID: 6289;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02018-05-29 03:48:56ID requested
12019-03-01 01:47:53announced
22024-10-22 04:06:18announced2024-10-22: Updated project metadata.
Publication List
Dataset with its publication pending
Keyword List
curator keyword: Biomedical
submitter keyword: Haemonchus contortus,Parasitic nematode, LC-MS/MS
Contact List
Robin Beat Gasser
contact affiliationDepartment of Veterinary Biosciences, Melbourne Veterinary School, The University of Melbourne, Parkville, Victoria 3010, Australia
contact emailrobinbg@unimelb.edu.au
lab head
Tao Wang
contact affiliationThe University of Melbourne
contact emailtao.wang1@unimelb.edu.au
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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